Human Donor Liver and Serum Concentrations of Perfluorooctanesulfonate and Other Perfluorochemicals

Perfluorooctanesulfonate (PFOS, C8F17SO3 -) has been identified in the serum of nonoccupationally exposed humans and in serum and liver tissue in wildlife. The purpose of this investigation was to determine whether PFOS liver concentrations in humans are comparable to the approximate 30 ng/mL averag...

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Bibliographic Details
Published in:Environmental science & technology 2003-03, Vol.37 (5), p.888-891
Main Authors: Olsen, Geary W, Hansen, Kristen J, Stevenson, Lisa A, Burris, Jean M, Mandel, Jeffrey H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alkanesulfonic Acids - pharmacokinetics
Biological and medical sciences
Chemicals
Child
Child, Preschool
Chromatography, Liquid
Environmental Exposure
Environmental impact
Environmental Pollutants - pharmacokinetics
Environmental pollutants toxicology
Female
Fluorocarbons - pharmacokinetics
General aspects
Humans
Liver
Liver - chemistry
Male
Mass Spectrometry
Medical sciences
Middle Aged
Reference Values
Risk Assessment
Tissue Distribution
Toxicology
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Summary:Perfluorooctanesulfonate (PFOS, C8F17SO3 -) has been identified in the serum of nonoccupationally exposed humans and in serum and liver tissue in wildlife. The purpose of this investigation was to determine whether PFOS liver concentrations in humans are comparable to the approximate 30 ng/mL average serum concentrations reported in nonoccupationally exposed subjects. Thirty-one donors (16 male and 15 female, age range 5−74) provided serum and/or liver samples for analysis of PFOS and three other fluorochemicals:  perfluorosulfonamide (PFOSA, C8F17SO2NH2), perfluorooctanoate (PFOA, C7F15CO2 -), and perfluorohexanesulfonate (PFHxS, C6F13SO3 -). Both sera and liver samples were extracted by ion-pair extraction and quantitatively assayed using high-performance liquid chromatography electrospray tandem mass spectrometry. Liver PFOS concentrations ranged from
ISSN:0013-936X
1520-5851
DOI:10.1021/es020955c