Association of Chronic and Current Measures of Lead Exposure with Different Components of Brainstem Auditory Evoked Potentials

Current blood lead (PbB) affects brainstem auditory evoked potentials (BAEPs) in children but whether a similar association exists in lead-exposed adults remains unclear. During an investigation of the neurobehavioral effects of occupational lead exposure we performed BAEPs on 359 English- and Frenc...

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Bibliographic Details
Published in:Neurotoxicology (Park Forest South) 2003-08, Vol.24 (4), p.625-631
Main Authors: Bleecker, Margit L, Patrick Ford, D, Lindgren, Karen N, Scheetz, Karin, Tiburzi, Michael J
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adult
Analysis of Variance
Biological and medical sciences
Blood lead
Brainstem auditory evoked potentials
Chemical and industrial products toxicology. Toxic occupational diseases
Cross-Sectional Studies
Cumulative blood lead
Dose-Response Relationship, Drug
Evoked Potentials, Auditory, Brain Stem - drug effects
Evoked Potentials, Auditory, Brain Stem - physiology
Humans
Lead - administration & dosage
Lead - blood
Lead - toxicity
Lead Poisoning, Nervous System, Adult - blood
Linear Models
Male
Medical sciences
Metals and various inorganic compounds
Middle Aged
Occupational Exposure - analysis
Toxicology
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Summary:Current blood lead (PbB) affects brainstem auditory evoked potentials (BAEPs) in children but whether a similar association exists in lead-exposed adults remains unclear. During an investigation of the neurobehavioral effects of occupational lead exposure we performed BAEPs on 359 English- and French-speaking, currently exposed, male, lead smelter workers having a mean (S.D.) age of 41 (9.0) years, employment duration of 17 (7.9) years, PbB of 28 (8.4) μg/dl, working-lifetime weighted average blood lead (TWA) of 39 (11.9) μg/dl, and working-lifetime integrated blood lead (IBL) index of 719 (421.0) μg·year/dl, the latter a measure of cumulative lead dose. BAEPs were performed at a click stimulation of 10 s −1 for 1000 repetitions, at an intensity 75 dB above the threshold of the ear tested. Right-sided latencies for peak waves I, III, and V and the corresponding interpeak intervals (IPI) I–V, I–III, and III–V were chosen for analyses. Age correlated significantly with BAEPs, PbB, TWA, and IBL. Partial correlation analyses adjusting for age found PbB and TWA significantly associated with wave I latency r=0.13, P
ISSN:0161-813X
1872-9711
DOI:10.1016/S0161-813X(03)00045-7