Pathogenic Mechanisms of Cryptosporidium and Giardia

Intestinal protozoa are important etiological agents of diarrhea, particularly in children, yet the public health risk they pose is often neglected. Results from the Global Enteric Multicenter Study (GEMS) showed that Cryptosporidium is among the leading causes of moderate to severe diarrhea in chil...

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Bibliographic Details
Published in:Trends in parasitology 2017-07, Vol.33 (7), p.561-576
Main Authors: Certad, Gabriela, Viscogliosi, Eric, Chabé, Magali, Cacciò, Simone M
Format: Article
Language:English
Subjects:
Age Factors
Cryptosporidiosis - parasitology
Cryptosporidiosis - physiopathology
Cryptosporidium
Cryptosporidium - pathogenicity
Gastroenterology and Hepatology
Giardia
Giardia - pathogenicity
Giardiasis - parasitology
Giardiasis - physiopathology
Humans
Infectious Disease
parasite–host factor interaction
virulence
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Summary:Intestinal protozoa are important etiological agents of diarrhea, particularly in children, yet the public health risk they pose is often neglected. Results from the Global Enteric Multicenter Study (GEMS) showed that Cryptosporidium is among the leading causes of moderate to severe diarrhea in children under 2 years. Likewise, Giardia infects approximately 200 million individuals worldwide, and causes acute diarrhea in children under 5 years. Despite this recognized role as pathogens, the question is why and how these parasites cause disease in some individuals but not in others. This review focuses on known pathogenic mechanisms of Cryptosporidium and Giardia , and infection progress towards disease.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2017.02.006