Exogenous hydrogen sulfide eliminates spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress via promoting glutamate uptake

Highlights • Exogenous H2 S prevents spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress. • The activation of glutamate transporters is necessary for exogenous H2 S to exert its roles. • Exogenous H2 S promotes glutamate uptake by reducing disulfide bonds o...

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Bibliographic Details
Published in:Neuroscience 2017-05, Vol.350, p.110-123
Main Authors: He, Jin, Guo, Ruixian, Qiu, Pengxin, Su, Xingwen, Yan, Guangmei, Feng, Jianqiang
Format: Article
Language:English
Subjects:
acute stress
Animals
glutamate transporters
Glutamic Acid - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
hydrogen sulfide
Hydrogen Sulfide - pharmacology
long-term depression
Long-Term Synaptic Depression - physiology
Male
Memory Disorders - metabolism
memory retrieval
Neurology
Neuronal Plasticity - physiology
Rats, Sprague-Dawley
Spatial Memory - drug effects
Stress, Psychological - metabolism
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Summary:Highlights • Exogenous H2 S prevents spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress. • The activation of glutamate transporters is necessary for exogenous H2 S to exert its roles. • Exogenous H2 S promotes glutamate uptake by reducing disulfide bonds of the glutamate transporters. • Exogenous H2 S has these protective effects by inhibiting the JNK signaling pathway.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.03.018