sNCAM as a specific marker of peripheral demyelination

Highlights • sNCAM was measured in sera of patients with various types of polyneuropathies. • Increased sNCAM was found in demyelinating versus axonal polyneuropathies and in axonal polyneuropathies versus healthy controls. • sNCAM concentration positively correlated with ONLS and negatively with th...

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Bibliographic Details
Published in:Immunology letters 2017-05, Vol.185, p.93-97
Main Authors: Niezgoda, Adam, Michalak, Sławomir, Losy, Jacek, Kalinowska-Łyszczarz, Alicja, Kozubski, Wojciech
Format: Article
Language:English
Subjects:
Adhesion molecules
Adult
Aged
Allergy and Immunology
Axonal polyneuropathy
Axons - metabolism
Axons - pathology
Biomarkers - blood
Demyelinating Diseases - diagnosis
Demyelinating polyneuropathy
Disease Progression
Electroneurography
ELISA immune assay
Female
Humans
Male
Middle Aged
NCAM
Neural Cell Adhesion Molecules - blood
Neural Conduction
Overall Neuropathy Limitations Scale
Peripheral nerve inflammation
Peripheral Nervous System Diseases - diagnosis
Severity of Illness Index
Young Adult
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Summary:Highlights • sNCAM was measured in sera of patients with various types of polyneuropathies. • Increased sNCAM was found in demyelinating versus axonal polyneuropathies and in axonal polyneuropathies versus healthy controls. • sNCAM concentration positively correlated with ONLS and negatively with the lowest conduction velocity.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2017.03.011