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sNCAM as a specific marker of peripheral demyelination

Highlights • sNCAM was measured in sera of patients with various types of polyneuropathies. • Increased sNCAM was found in demyelinating versus axonal polyneuropathies and in axonal polyneuropathies versus healthy controls. • sNCAM concentration positively correlated with ONLS and negatively with th...

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Published in:	Immunology letters 2017-05, Vol.185, p.93-97
Main Authors:	Niezgoda, Adam, Michalak, Sławomir, Losy, Jacek, Kalinowska-Łyszczarz, Alicja, Kozubski, Wojciech
Format:	Article
Language:	English
Subjects:	Adhesion molecules Adult Aged Allergy and Immunology Axonal polyneuropathy Axons - metabolism Axons - pathology Biomarkers - blood Demyelinating Diseases - diagnosis Demyelinating polyneuropathy Disease Progression Electroneurography ELISA immune assay Female Humans Male Middle Aged NCAM Neural Cell Adhesion Molecules - blood Neural Conduction Overall Neuropathy Limitations Scale Peripheral nerve inflammation Peripheral Nervous System Diseases - diagnosis Severity of Illness Index Young Adult
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container_title	Immunology letters
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creator	Niezgoda, Adam Michalak, Sławomir Losy, Jacek Kalinowska-Łyszczarz, Alicja Kozubski, Wojciech
description	Highlights • sNCAM was measured in sera of patients with various types of polyneuropathies. • Increased sNCAM was found in demyelinating versus axonal polyneuropathies and in axonal polyneuropathies versus healthy controls. • sNCAM concentration positively correlated with ONLS and negatively with the lowest conduction velocity.
doi_str_mv	10.1016/j.imlet.2017.03.011
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subjects	Adhesion molecules Adult Aged Allergy and Immunology Axonal polyneuropathy Axons - metabolism Axons - pathology Biomarkers - blood Demyelinating Diseases - diagnosis Demyelinating polyneuropathy Disease Progression Electroneurography ELISA immune assay Female Humans Male Middle Aged NCAM Neural Cell Adhesion Molecules - blood Neural Conduction Overall Neuropathy Limitations Scale Peripheral nerve inflammation Peripheral Nervous System Diseases - diagnosis Severity of Illness Index Young Adult
title	sNCAM as a specific marker of peripheral demyelination
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