Biomaterials Innovation for Next Generation Ex Vivo Immune Tissue Engineering

Abstract Primary and secondary lymphoid organs are tissues that facilitate differentiation of B and T cells leading to the induction of adaptive immune responses. These organs are present in the body right from birth and are now also recognized as locations where self-reactive B and T cells can be e...

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Bibliographic Details
Published in:Biomaterials 2017-06, Vol.130, p.104-110
Main Author: Singh, Ankur
Format: Article
Language:English
Subjects:
Adhesive
Advanced Basic Science
Animals
Biocompatible Materials - pharmacology
Cellular Microenvironment
Dentistry
Humans
Hydrogel
Immune System - physiology
Lymph node
Lymph Nodes - cytology
Microfluidics
Organoids
Spatio-temporal
T-Lymphocytes - cytology
Tissue Engineering - methods
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Summary:Abstract Primary and secondary lymphoid organs are tissues that facilitate differentiation of B and T cells leading to the induction of adaptive immune responses. These organs are present in the body right from birth and are now also recognized as locations where self-reactive B and T cells can be eliminated during the selection process. Many insights into mechanism that control the process of immune cell development and maturation in response to infection come from the analysis of various gene-deficient mice that lack some or all lymphoid tissues. The complexity of such animal models limits our ability to modulate the parameters that control the process of immune cell development, differentiation, and immunomodulation. Engineering functional, living immune tissues using biomaterials can grant researchers the ability to reproduce immunological events with tunable parameters for more rapid development of immunotherapeutics, cell-based therapy, and enhance our understanding of fundamental biology as well as improve efforts in regenerative medicine. Here the author provides his review and perspective on the bioengineering of primary and secondary lymphoid tissues, and biomaterials innovation needed for the construction of these immune organs in tissue culture plates and on-chip.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2017.03.015