Mortality Risk Stratification in Fontan Patients Who Underwent Heart Transplantation

The number of patients who require orthotopic heart transplantation (OHT) for failing Fontan physiology continues to grow; however, the methods and tools to evaluate risk of OHT are limited. This study aimed to identify a set of preoperative variables and characteristics that were associated with a...

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Bibliographic Details
Published in:The American journal of cardiology 2017-05, Vol.119 (10), p.1675-1679
Main Authors: Berg, Christopher J., Bauer, Brenton S., Hageman, Abbie, Aboulhosn, Jamil A., Reardon, Leigh C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
California - epidemiology
Cardiovascular disease
Cause of Death - trends
Child
Child, Preschool
Congenital diseases
Female
Follow-Up Studies
Fontan Procedure - adverse effects
Fontan Procedure - mortality
Health care facilities
Health risk assessment
Health risks
Heart
Heart Defects, Congenital - mortality
Heart Defects, Congenital - surgery
Heart surgery
Heart transplantation
Heart Transplantation - mortality
Heart transplants
Humans
Incidence
Liver
Liver diseases
Male
Mortality
Patients
Physiology
Postoperative Period
Reoperation
Retrospective Studies
Risk analysis
Risk Assessment - methods
Risk Factors
Survival Rate - trends
Time Factors
Transplantation
Transplants & implants
Treatment Outcome
Ventricle
Young Adult
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Summary:The number of patients who require orthotopic heart transplantation (OHT) for failing Fontan physiology continues to grow; however, the methods and tools to evaluate risk of OHT are limited. This study aimed to identify a set of preoperative variables and characteristics that were associated with a greater risk of postoperative mortality in patients who received OHT for failing Fontan physiology. Thirty-six Fontan patients were identified as having undergone OHT at University of California-Los Angeles Medical Center from 1991 to 2014. Data were collected retrospectively and analyzed. The primary end point was designated as postoperative mortality. After an average follow-up time of 3.5 years, 17 (44%) patients suffered postoperative mortality. Patient characteristics including (1) age
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2017.02.005