Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report

Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. We present a kidney tran...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2017-04, Vol.49 (3), p.609-612
Main Authors: Bayraktar, A, Bakkaloglu, H, Demir, E, Turkmen, A, Azamat, I F, Caliskan, Y, Sari, Ş O, Buyukbabani, N, Baykal, C, Aydin, A E
Format: Article
Language:English
Subjects:
Acrodermatitis - drug therapy
Acrodermatitis - etiology
Acrodermatitis - pathology
Dermatologic Agents - therapeutic use
Diarrhea - etiology
Epidermis - pathology
Foot Dermatoses - drug therapy
Foot Dermatoses - etiology
Foot Dermatoses - pathology
Hand Dermatoses - drug therapy
Hand Dermatoses - etiology
Hand Dermatoses - pathology
Humans
Keratinocytes - pathology
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Male
Young Adult
Zinc - deficiency
Zinc - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. We present a kidney transplant recipient with skin rash and watery diarrhea. The patient had low serum zinc levels, which quickly resolved after zinc supplementation. Skin biopsy showed cytoplasmic pallor and vacuolization and ballooning degeneration of keratinocytes within the superficial epidermis, which may have led to confluent necrosis of keratinocytes. Large amounts of keratinosome-derived lamellae were found in the intercellular spaces in the keratinized area, probably related to disturbance of keratinosome metabolism due to zinc deficiency.
ISSN:1873-2623
DOI:10.1016/j.transproceed.2017.02.030