Inactivation of dermatophyte infection by nonthermal plasma on animal model

Abstract Superficial fungal infections are a major epidemiological issue with increasing prevalence and are a common global problem. This article describes experimental therapy of superficial fungal skin infection using low-temperature plasma. Groups of guinea pigs were artificially infected with Tr...

Full description

Saved in:
Bibliographic Details
Published in:Medical mycology (Oxford) 2017-06, Vol.55 (4), p.422-428
Main Authors: Scholtz, Vladimír, Soušková, Hana, Švarcová, Michaela, Kříha, Vítězslav, Živná, Helena, Julák, Jaroslav
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antifungal Agents - therapeutic use
Dermatomycoses - therapy
Disease Models, Animal
Female
Guinea Pigs
Male
Plasma Gases - therapeutic use
Treatment Outcome
Trichophyton - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Superficial fungal infections are a major epidemiological issue with increasing prevalence and are a common global problem. This article describes experimental therapy of superficial fungal skin infection using low-temperature plasma. Groups of guinea pigs were artificially infected with Trichophyton mentagrophytes SK 3286 dermatophyte and treated with plasma produced by a DC cometary discharge with an inserted grid. The course of infection was a week shorter and milder in animals treated by plasma than that in nontreated animals, the significant lowering of dermatophytic germs also occurred in the treated group. The exposure to plasma causes no harm to experimental animals. The results allow for the development of a new dermatophytoses therapy by low temperature plasma treatment.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myw094