Bioactive constituents from transformed root cultures of Nepeta teydea

• Published in: Phytochemistry (Oxford) 2017-01, Vol.133, p.59-68
• Main Authors: Fraga, Braulio M., González-Coloma, Azucena, Alegre-Gómez, Sergio, López-Rodríguez, Matías, Amador, Leonardo J., Díaz, Carmen E.
• Format: Article
• Language: English
• Subjects: (-)-Cinalbicol; Animals; Biological activity; CHO Cells; Cricetinae; Cricetulus; Culture Techniques; Cytotoxins - chemistry; Cytotoxins - isolation & purification; Cytotoxins - toxicity; Diterpenes; Insecticides - chemistry; Insecticides - isolation & purification; Lamiaceae; Nepeta - chemistry; Nepeta - growth & development; Nepeta teydea; Phenolic compounds; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - toxicity; Plant Roots - chemistry; Plant Roots - growth & development; Sesquiterpenes; Spodoptera; Teydeadione; Teydealdehyde; Transformed root cultures; Triterpenes
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2016.10.008

A phytochemical study of an extract from transformed root cultures of Nepeta teydea, induced by Agrobacterium rhizogenes, led to the isolation of the following new compounds: the sesquiterpene (-)-cinalbicol, the diterpene teydeadione (6,11,14-trihydroxy-12-methoxy-abieta-5,8,11,13,15-penten-7-one), a degraded C23-triterpene (teydealdehyde) and three fatty acid esters of lanosta-7,24-dien-3β-ol. The propyl ester of rosmarinic acid was also isolated for the first time from a natural source. In addition, two dehydroabietane diterpenes, eight triterpenes and eighteen known phenolic compounds were obtained. The antifeedant, cytotoxic and phytotoxic activities of the isolated compounds have also been investigated. A study of Nepeta teydea root cultures afforded the undescribed compounds (-)-cinalbicol, teydeadione, teydealdehyde, and three fatty esters of lanosta-7,24-dien-3β-ol. The antifeedant, cytotoxic and phytotoxic activities of the constituents of the root cultures have also been investigated. [Display omitted] •Components of transformed root cultures of Nepeta teydea have been studied.•New compounds: (-)-cinalbicol, teydeadione, teydealdehyde, lanostadiene esters.•The antifeedant, cytotoxic and phytotoxic activities have been investigated.