New Nematotoxic Indoloditerpenoid Produced by Gymnoascus reessii za-130

Chemical investigation of the fungal strain Gymnoascus reessii za-130, which was previously isolated from the rhizosphere of tomato plants infected by the root-knot nematode Meloidogyne incognita, led to the isolation and identification of a new indoloditerpenoid metabolite designated gymnoascole ac...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2017-04, Vol.65 (15), p.3127-3132
Main Authors: Liu, Ting, Meyer, Susan L. F, Chitwood, David J, Chauhan, Kamlesh R, Dong, Dan, Zhang, TaoTao, Li, Jun, Liu, Wei-cheng
Format: Article
Language:English
Subjects:
Animals
Antinematodal Agents - chemistry
Antinematodal Agents - metabolism
Antinematodal Agents - pharmacology
Ascomycota - chemistry
Diterpenes - chemistry
Diterpenes - metabolism
Diterpenes - pharmacology
Lycopersicon esculentum - parasitology
Plant Diseases - parasitology
Plant Roots - parasitology
Tylenchoidea - drug effects
Tylenchoidea - growth & development
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Summary:Chemical investigation of the fungal strain Gymnoascus reessii za-130, which was previously isolated from the rhizosphere of tomato plants infected by the root-knot nematode Meloidogyne incognita, led to the isolation and identification of a new indoloditerpenoid metabolite designated gymnoascole acetate. Its structure was established by spectroscopic methods including 1D- and 2D-NMR and MS analyses. Gymnoascole acetate demonstrated strong adverse effects on M. incognita second-stage juvenile (J2) viability; exposure to 36 μg/mL for 24 h induced 100% paralysis of J2 (EC50 = 47.5 μg/mL). Gymnoascole acetate suppressed M. incognita egg hatch relative to controls by >90% at 133 μg/mL after 7 days of exposure. The numbers of root galls and J2 in both soil and roots were significantly reduced (p = 0.05) by treatment with 2–200 μg/mL gymnoascole acetate/kg soil, compared to untreated control plants; nematode suppression increased with gymnoascole acetate concentration. This study demonstrated the nematotoxicity of gymnoascole acetate and indicates that it might be a potential biobased component in integrated management of M. incognita.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.6b04353