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Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood–brain barrier dysfunction in vitro

Highlights • Brain pericytes expressed PAR1 and PAR4 proteins. • Brain pericytes released MMP-9 through PAR1-PKCθ-Akt and PAR1-PKCδ-ERK1/2 pathway. • Thrombin stimulated PAR1 on brain pericytes to induce BBB dysfunction by releasing soluble factors including MMP-9.

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Bibliographic Details
Published in:Neuroscience 2017-05, Vol.350, p.146-157
Main Authors: Machida, Takashi, Dohgu, Shinya, Takata, Fuyuko, Matsumoto, Junichi, Kimura, Ikuya, Koga, Mariko, Nakamoto, Keiko, Yamauchi, Atsushi, Kataoka, Yasufumi
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Language:English
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Summary:Highlights • Brain pericytes expressed PAR1 and PAR4 proteins. • Brain pericytes released MMP-9 through PAR1-PKCθ-Akt and PAR1-PKCδ-ERK1/2 pathway. • Thrombin stimulated PAR1 on brain pericytes to induce BBB dysfunction by releasing soluble factors including MMP-9.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.03.026