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Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood–brain barrier dysfunction in vitro
Highlights • Brain pericytes expressed PAR1 and PAR4 proteins. • Brain pericytes released MMP-9 through PAR1-PKCθ-Akt and PAR1-PKCδ-ERK1/2 pathway. • Thrombin stimulated PAR1 on brain pericytes to induce BBB dysfunction by releasing soluble factors including MMP-9.
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Published in: | Neuroscience 2017-05, Vol.350, p.146-157 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Brain pericytes expressed PAR1 and PAR4 proteins. • Brain pericytes released MMP-9 through PAR1-PKCθ-Akt and PAR1-PKCδ-ERK1/2 pathway. • Thrombin stimulated PAR1 on brain pericytes to induce BBB dysfunction by releasing soluble factors including MMP-9. |
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ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2017.03.026 |