A novel live attenuated anthrax spore vaccine based on an acapsular Bacillus anthracis Sterne strain with mutations in the htrA , lef and cya genes

Highlights • A novel safe and efficacious anthrax live vaccine based on the Sterne strain was generated. • This vaccine exhibits disruption of htrA and cya genes and mutation of the lef gene. • The vaccine retains its ability to elicit protective immune response in guinea pigs and rabbits. • The vac...

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Bibliographic Details
Published in:Vaccine 2017-10, Vol.35 (44), p.6030-6040
Main Authors: Chitlaru, Theodor, Israeli, Ma'ayan, Rotem, Shahar, Elia, Uri, Bar-Haim, Erez, Ehrlich, Sharon, Cohen, Ofer, Shafferman, Avigdor
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal models
Animals
Anthrax
Anthrax - immunology
Anthrax - prevention & control
Anthrax toxins
Anthrax Vaccines - genetics
Anthrax Vaccines - immunology
Antibodies, Bacterial - immunology
Antigens
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Attenuation
Bacillus anthracis
Bacillus anthracis - genetics
Bacillus anthracis - immunology
Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Bacterial Toxins - genetics
Bacterial Toxins - immunology
Edema
Female
Genes
Genes, Bacterial - genetics
Genes, Bacterial - immunology
Guinea Pigs
High temperature
HtrA
Humans
Immune response
Immune status
Immune system
Immunity
Immunization
Infections
Lethal factor
Live attenuated vaccine
Mice
Mice, Inbred ICR
Mutation
Mutation - genetics
Mutation - immunology
Pathogenesis
Protective antigen
Proteins
Public health
Rabbits
Respiration
Serine Endopeptidases - genetics
Serine Endopeptidases - immunology
Spores, Bacterial - genetics
Spores, Bacterial - immunology
Swine
Temperature requirements
Toxins
Vaccination - methods
Vaccines
Vaccines, Attenuated - genetics
Vaccines, Attenuated - immunology
Veterinary medicine
Virulence
Virulence - genetics
Virulence - immunology
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Summary:Highlights • A novel safe and efficacious anthrax live vaccine based on the Sterne strain was generated. • This vaccine exhibits disruption of htrA and cya genes and mutation of the lef gene. • The vaccine retains its ability to elicit protective immune response in guinea pigs and rabbits. • The vaccine exhibits an extended therapeutic window therefore may be compatible with human use.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.03.033