Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hos...

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Bibliographic Details
Published in:Revista Brasileira de Reumatologia 2017-03, Vol.57 (2), p.149-153
Main Authors: Taha, Sherif, Gamal, Sherif Mohammed, Nabil, Mohamed, Naeem, Nahla, Labib, Dalia, Siam, Ibrahim, Gheita, Tamer Atef
Format: Article
Language:eng ; por
Subjects:
Gene G1612A (rs10434)
LES
Manifestações neuropsiquiátricas
Polimorfismo
VEGF
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Summary:To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p
ISSN:2255-5021
1809-4570
2255-5021
DOI:10.1016/j.rbre.2016.11.007