Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hos...

Full description

Saved in:
Bibliographic Details
Published in:Revista Brasileira de Reumatologia 2017-03, Vol.57 (2), p.149-153
Main Authors: Taha, Sherif, Gamal, Sherif Mohammed, Nabil, Mohamed, Naeem, Nahla, Labib, Dalia, Siam, Ibrahim, Gheita, Tamer Atef
Format: Article
Language:eng ; por
Subjects:
Gene G1612A (rs10434)
LES
Manifestações neuropsiquiátricas
Polimorfismo
VEGF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473
cites cdi_FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473
container_end_page 153
container_issue 2
container_start_page 149
container_title Revista Brasileira de Reumatologia
container_volume 57
creator Taha, Sherif
Gamal, Sherif Mohammed
Nabil, Mohamed
Naeem, Nahla
Labib, Dalia
Siam, Ibrahim
Gheita, Tamer Atef
description To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p
doi_str_mv 10.1016/j.rbre.2016.11.007
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881449499</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b11eae4348ce400caf41f3f1cb035af2</doaj_id><sourcerecordid>1881449499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473</originalsourceid><addsrcrecordid>eNpNkcFu1DAQhiMEolXpC3BAPpbDBo_tTbLHqoJSqRIX4GpNnPGuV04cbEcor9EnxsuWipPH43_-8a-vqt4Dr4FD8-lYxz5SLUpdA9Sct6-qSyG2282WC3j9X31RXad05JxDq4SQ_G11ITqpZCP4ZfX0E5NZPEZG0xDygbxDz_Yx_M4HZtHkENk9NCBu2U1MwJVUH9meJmJz8OsY4nxwaWQ4DWyiJYY5rebgMEdn2IiTs5QyZhemxNzE0poyjeXJL_OSGMW1bBwxh1Ruc9HRlNO76o1Fn-j6-byqfnz5_P3u6-bx2_3D3e3jxkgh86b8X4qBDFe95NYK3EHXDB21PTWia6wU2MqeW7C2kw10Ekr2_tQ2yoBq5VX1cPYdAh71HN2IcdUBnf7bCHGvMWZnPOkegJBK9s6Q4tygVWClBdNzuUUritfN2WuO4ddSMuvRJUPe40RhSRq6DpTaqd2uSMVZamJIKZJ9WQ1cn9Dqoz6h1Se0GkAXtGXow7P_0o80vIz8Ayn_AEeeol0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1881449499</pqid></control><display><type>article</type><title>Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients</title><source>ScienceDirect®</source><creator>Taha, Sherif ; Gamal, Sherif Mohammed ; Nabil, Mohamed ; Naeem, Nahla ; Labib, Dalia ; Siam, Ibrahim ; Gheita, Tamer Atef</creator><creatorcontrib>Taha, Sherif ; Gamal, Sherif Mohammed ; Nabil, Mohamed ; Naeem, Nahla ; Labib, Dalia ; Siam, Ibrahim ; Gheita, Tamer Atef</creatorcontrib><description>To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p&lt;0.001] and GG [10% vs 66.7%, p&lt;0.001]). Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.</description><identifier>ISSN: 2255-5021</identifier><identifier>ISSN: 1809-4570</identifier><identifier>EISSN: 2255-5021</identifier><identifier>DOI: 10.1016/j.rbre.2016.11.007</identifier><identifier>PMID: 28343620</identifier><language>eng ; por</language><publisher>Brazil: Sociedade Brasileira de Reumatologia</publisher><subject>Gene G1612A (rs10434) ; LES ; Manifestações neuropsiquiátricas ; Polimorfismo ; VEGF</subject><ispartof>Revista Brasileira de Reumatologia, 2017-03, Vol.57 (2), p.149-153</ispartof><rights>Copyright © 2016 Elsevier Editora Ltda. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473</citedby><cites>FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28343620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taha, Sherif</creatorcontrib><creatorcontrib>Gamal, Sherif Mohammed</creatorcontrib><creatorcontrib>Nabil, Mohamed</creatorcontrib><creatorcontrib>Naeem, Nahla</creatorcontrib><creatorcontrib>Labib, Dalia</creatorcontrib><creatorcontrib>Siam, Ibrahim</creatorcontrib><creatorcontrib>Gheita, Tamer Atef</creatorcontrib><title>Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients</title><title>Revista Brasileira de Reumatologia</title><addtitle>Rev Bras Reumatol Engl Ed</addtitle><description>To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p&lt;0.001] and GG [10% vs 66.7%, p&lt;0.001]). Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.</description><subject>Gene G1612A (rs10434)</subject><subject>LES</subject><subject>Manifestações neuropsiquiátricas</subject><subject>Polimorfismo</subject><subject>VEGF</subject><issn>2255-5021</issn><issn>1809-4570</issn><issn>2255-5021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpNkcFu1DAQhiMEolXpC3BAPpbDBo_tTbLHqoJSqRIX4GpNnPGuV04cbEcor9EnxsuWipPH43_-8a-vqt4Dr4FD8-lYxz5SLUpdA9Sct6-qSyG2282WC3j9X31RXad05JxDq4SQ_G11ITqpZCP4ZfX0E5NZPEZG0xDygbxDz_Yx_M4HZtHkENk9NCBu2U1MwJVUH9meJmJz8OsY4nxwaWQ4DWyiJYY5rebgMEdn2IiTs5QyZhemxNzE0poyjeXJL_OSGMW1bBwxh1Ruc9HRlNO76o1Fn-j6-byqfnz5_P3u6-bx2_3D3e3jxkgh86b8X4qBDFe95NYK3EHXDB21PTWia6wU2MqeW7C2kw10Ekr2_tQ2yoBq5VX1cPYdAh71HN2IcdUBnf7bCHGvMWZnPOkegJBK9s6Q4tygVWClBdNzuUUritfN2WuO4ddSMuvRJUPe40RhSRq6DpTaqd2uSMVZamJIKZJ9WQ1cn9Dqoz6h1Se0GkAXtGXow7P_0o80vIz8Ayn_AEeeol0</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Taha, Sherif</creator><creator>Gamal, Sherif Mohammed</creator><creator>Nabil, Mohamed</creator><creator>Naeem, Nahla</creator><creator>Labib, Dalia</creator><creator>Siam, Ibrahim</creator><creator>Gheita, Tamer Atef</creator><general>Sociedade Brasileira de Reumatologia</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>201703</creationdate><title>Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients</title><author>Taha, Sherif ; Gamal, Sherif Mohammed ; Nabil, Mohamed ; Naeem, Nahla ; Labib, Dalia ; Siam, Ibrahim ; Gheita, Tamer Atef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2017</creationdate><topic>Gene G1612A (rs10434)</topic><topic>LES</topic><topic>Manifestações neuropsiquiátricas</topic><topic>Polimorfismo</topic><topic>VEGF</topic><toplevel>online_resources</toplevel><creatorcontrib>Taha, Sherif</creatorcontrib><creatorcontrib>Gamal, Sherif Mohammed</creatorcontrib><creatorcontrib>Nabil, Mohamed</creatorcontrib><creatorcontrib>Naeem, Nahla</creatorcontrib><creatorcontrib>Labib, Dalia</creatorcontrib><creatorcontrib>Siam, Ibrahim</creatorcontrib><creatorcontrib>Gheita, Tamer Atef</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revista Brasileira de Reumatologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taha, Sherif</au><au>Gamal, Sherif Mohammed</au><au>Nabil, Mohamed</au><au>Naeem, Nahla</au><au>Labib, Dalia</au><au>Siam, Ibrahim</au><au>Gheita, Tamer Atef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients</atitle><jtitle>Revista Brasileira de Reumatologia</jtitle><addtitle>Rev Bras Reumatol Engl Ed</addtitle><date>2017-03</date><risdate>2017</risdate><volume>57</volume><issue>2</issue><spage>149</spage><epage>153</epage><pages>149-153</pages><issn>2255-5021</issn><issn>1809-4570</issn><eissn>2255-5021</eissn><abstract>To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR). Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p&lt;0.001] and GG [10% vs 66.7%, p&lt;0.001]). Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reumatologia</pub><pmid>28343620</pmid><doi>10.1016/j.rbre.2016.11.007</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2255-5021
ispartof Revista Brasileira de Reumatologia, 2017-03, Vol.57 (2), p.149-153
issn 2255-5021
1809-4570
2255-5021
language eng ; por
recordid cdi_proquest_miscellaneous_1881449499
source ScienceDirect®
subjects Gene G1612A (rs10434)
LES
Manifestações neuropsiquiátricas
Polimorfismo
VEGF
title Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T18%3A14%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vascular%20endothelial%20growth%20factor%20G1612A%20(rs10434)%20gene%20polymorphism%20and%20neuropsychiatric%20manifestations%20in%20systemic%20lupus%20erythematosus%20patients&rft.jtitle=Revista%20Brasileira%20de%20Reumatologia&rft.au=Taha,%20Sherif&rft.date=2017-03&rft.volume=57&rft.issue=2&rft.spage=149&rft.epage=153&rft.pages=149-153&rft.issn=2255-5021&rft.eissn=2255-5021&rft_id=info:doi/10.1016/j.rbre.2016.11.007&rft_dat=%3Cproquest_doaj_%3E1881449499%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c323t-36232dec04b30ff2a9186d8e7be6286f32a73b0f1ff8361831230bf32ac4c1473%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1881449499&rft_id=info:pmid/28343620&rfr_iscdi=true