Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: reduced dopaminergic modulation and immediate gene expression in limbic circuits

Highlights • Cannabidiol into prefrontal cortex impaired fear memory consolidation only when it occurred at 5 h after conditioning. • Cannabidiol decreases dopamine release in prefrontal cortex following memory retrieval 5 days after training. • Post-training infusion of cannabidiol reduces genes ex...

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Published in:Neuroscience 2017-05, Vol.350, p.85-93
Main Authors: Rossignoli, Matheus Teixeira, Lopes-Aguiar, Cleiton, Ruggiero, Rafael Naime, Do Val da Silva, Raquel Araujo, Bueno-Junior, Lezio Soares, Kandratavicius, Ludmyla, Peixoto-Santos, José Eduardo, Crippa, José Alexandre, Cecilio Hallak, Jaime Eduardo, Zuardi, Antonio Waldo, Szawka, Raphael Escorsim, Anselmo-Franci, Janete, Leite, João Pereira, Romcy-Pereira, Rodrigo Neves
Format: Article
Language:English
Subjects:
Animals
C-fos
cannabidiol
Cannabidiol - pharmacology
Conditioning (Psychology) - drug effects
contextual fear memory
dopamine
Fear - drug effects
Gene Expression - drug effects
Hippocampus - drug effects
Hippocampus - metabolism
Male
medial prefrontal cortex
Memory Consolidation - drug effects
Neurology
Neurons - metabolism
Prefrontal Cortex - drug effects
Prefrontal Cortex - metabolism
Rats, Wistar
Stress Disorders, Post-Traumatic - metabolism
Time Factors
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Summary:Highlights • Cannabidiol into prefrontal cortex impaired fear memory consolidation only when it occurred at 5 h after conditioning. • Cannabidiol decreases dopamine release in prefrontal cortex following memory retrieval 5 days after training. • Post-training infusion of cannabidiol reduces genes expression in cortico-limbic circuits following memory retrieval.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.03.019