Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women

• Published in: Clinical proteomics 2017, Vol.14, p.8-8
• Main Authors: Mary, Sheon, Kulkarni, Mahesh J, Mehendale, Savita S, Joshi, Sadhana R, Giri, Ashok P
• Format: Article
• Language: English
• Subjects: Acetonitrile; Actin; Alkylation; Angiogenesis; Animal models; Antibodies; Antigens; Apoptosis; Biochemistry; Bioinformatics; Biotechnology; Biotin; Blood flow; Capillaries; Computer programs; Embryos; Fragmentation; Gels; Gestation; Gynecology; Hypertension; Hypoxia; Identification; Immunology; Liver diseases; Lungs; Lysis; Organs; Particle size; Peptides; Placenta; Preeclampsia; Pregnancy; Proteins; Rodents; Smooth muscle; Software; Statistics; Task forces; Visual perception; Womens health
• ISSN: 1542-6416; 1559-0275
• DOI: 10.1186/s12014-017-9144-2

Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell culture and animal models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its expression in the decidua of postimplantation mouse uterus, prompted us to validate its expression in human placenta during impaired angiogenesis in pre-eclamptic condition. Placental tissue from normotensive (n = 25) and pre-eclamptic (n = 25) pregnancies were used to study the differentially expressed proteins by two-dimensional gel electrophoresis and TINAGL1 protein was validated with Western blotting. A total of 55 protein spots were differentially expressed (fold change >1.5, p