Normal values of regional left ventricular myocardial thickness, mass and distribution-assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study

Left ventricular (LV) hypertrophy is associated with cardiovascular complications and the geometry is important for prognosis. In some cardiovascular diseases, myocardial hypertrophy or dilation occurs regionally without modifying the global size of the heart. It is therefore relevant to determine r...

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Bibliographic Details
Published in:International Journal of Cardiovascular Imaging 2017-03, Vol.33 (3), p.421-429
Main Authors: Hindsø, Louise, Fuchs, Andreas, Kühl, Jørgen Tobias, Nilsson, Emma Julia P., Sigvardsen, Per Ejlstrup, Køber, Lars, Nordestgaard, Børge G., Kofoed, Klaus Fuglsang
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Algorithms
Cardiac Imaging
Cardiology
Computed Tomography Angiography - methods
Denmark
Female
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - pathology
Hypertrophy, Left Ventricular - physiopathology
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Multidetector Computed Tomography
Original Paper
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Radiology
Reference Values
Reproducibility of Results
Sex Factors
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Summary:Left ventricular (LV) hypertrophy is associated with cardiovascular complications and the geometry is important for prognosis. In some cardiovascular diseases, myocardial hypertrophy or dilation occurs regionally without modifying the global size of the heart. It is therefore relevant to determine regional normal reference values of the left ventricle. The aim of this study was to derive reference values of regional LV myocardial thickness (LVMT) and mass (LVMM) from a healthy study group of the general population using cardiac computed tomography angiography (CCTA). We wanted to introduce LV myocardial distribution (LVMD) as a measure of regional variation of the LVMT. Moreover, we wanted to determine whether these parameters varied between men and women. We studied 568 (181 men; 32%) adults, free of cardiovascular disease and risk factors, who underwent 320-detector CCTA. Mean age was 55 (range 40–84) years. Regional LVMT and LVMM were measured, according to the American Heart Association’s 17 segment model, using semi-automatic software. Mean LVMT were 6.6 mm for men and 5.4 mm for women (p 
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-016-1015-9