The role of metastasis‐associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression

Metastasis‐associated in colon cancer‐1 (MACC1), has recently been identified as a key regulator in the progression of many cancers. However, its role in endometrial carcinoma (EC) remains unknown. MACC1 expression was determined in EC and normal endometrial tissues by immunohistochemistry. EC cell...

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Bibliographic Details
Published in:Molecular carcinogenesis 2017-04, Vol.56 (4), p.1361-1371
Main Authors: Chen, Shuo, Zong, Zhi‐Hong, Wu, Dan‐dan, Sun, Kai‐Xuan, Liu, Bo‐Liang, Zhao, Yang
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis - genetics
Carcinogenesis - pathology
Cell growth
Cell Movement
Cell Proliferation
Colorectal cancer
Cyclin-dependent kinases
Down-Regulation
Endometrial cancer
endometrial carcinoma
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Endometrium - pathology
epithelial‐mesenchymal transition
Female
Gene Expression Regulation, Neoplastic
Humans
MACC1
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
MicroRNAs - genetics
Middle Aged
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
progression
Transcription Factors - genetics
Tumorigenesis
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Summary:Metastasis‐associated in colon cancer‐1 (MACC1), has recently been identified as a key regulator in the progression of many cancers. However, its role in endometrial carcinoma (EC) remains unknown. MACC1 expression was determined in EC and normal endometrial tissues by immunohistochemistry. EC cell phenotypes and related molecules were examined after MACC1 downregulation by Small interfering RNA (siRNA) or microRNA (miRNA) transfection. We found that MACC1 was highly expressed in EC tissues than normal samples, and was significantly different in FIGO staging (I and II vs. III and IV), the depth of myometrial infiltration (
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.22599