Mechanisms of long-term plasticity of hippocampal GABAergic synapses

Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal central nervous syste...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2017-03, Vol.82 (3), p.257-263
Main Authors: Rozov, A. V., Valiullina, F. F., Bolshakov, A. P.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Brain research
Central nervous system
GABAergic Neurons - metabolism
Hippocampus (Brain)
Hippocampus - physiology
Humans
Life Sciences
Long-Term Potentiation - physiology
Microbiology
Nervous system
Neurology
Neuronal Plasticity - physiology
Neuroplasticity
Neurotransmitters
Physiological aspects
Plasticity
Proteins
Review
Synapses
Synapses - metabolism
Synaptic Transmission - physiology
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Summary:Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal central nervous system functioning requires maintenance of a balance between inhibition and excitation, suggesting existence of similar modulation of glutamatergic and GABAergic synapses. Here we review the involvement of G-protein-coupled receptors in the generation of long-term changes in synaptic transmission of inhibitory synapses. We considered the role of endocannabinoid and glutamate systems, GABA B and opioid receptors in the induction of long-term potentiation and long-term depression in inhibitory synapses. The preand postsynaptic effects of activation of these receptors are also discussed.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297917030038