Oxidative stress markers after a race in professional cyclists

The aim was to determine the levels and activities of the oxidative stress markers in erythrocytes, plasma, and urine after a flat cyclist stage. Eight voluntary male professional trained-cyclists participated in the study. Exercise significantly increased erythrocyte, leukocyte, platelet, and retic...

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Bibliographic Details
Published in:International journal of sport nutrition and exercise metabolism 2015-04, Vol.25 (2), p.171-178
Main Authors: Córdova, Alfredo, Sureda, Antoni, Albina, María Luisa, Linares, Victoria, Bellés, Montse, Sánchez, Domènec J
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Athletes
Bicycling - physiology
Biomarkers - metabolism
Catalase - metabolism
Erythrocytes - metabolism
Exercise - physiology
F2-Isoprostanes - urine
Glutathione - blood
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Humans
Male
Malondialdehyde - blood
Oxidation-Reduction
Oxidative Stress
Physical Endurance - physiology
Young Adult
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Summary:The aim was to determine the levels and activities of the oxidative stress markers in erythrocytes, plasma, and urine after a flat cyclist stage. Eight voluntary male professional trained-cyclists participated in the study. Exercise significantly increased erythrocyte, leukocyte, platelet, and reticulocyte counts. The exercise induced significant increases in the erythrocyte activities of catalase (19.8%) and glutathione reductase (19.2%), while glutathione peroxidase activity decreased significantly (29.3%). Erythrocyte GSSG concentration was significantly increased after exercise (21.4%), whereas GSH was significantly diminished (20.4%). Erythrocyte malondialdehyde levels evidenced a significant decrease 3 h after finishing the stage (44.3%). Plasma malondialdehyde, GSH and GSSG levels significantly decreased after 3 hr recovery (26.8%, 48.6%, and 31.1%, respectively). The exercise significantly increased the F2-isoprostane concentration in urine from 359 ± 71 pg/mg creatinine to 686 ± 139 pg/mg creatinine. In conclusion, a flat cycling stage induced changes in oxidative stress markers in erythrocytes, plasma, and urine of professional cyclists. Urine F2-isoprostane is a more useful biomarker for assessing the effects of acute exercise than the traditional malondialdehyde measurement.
ISSN:1526-484X
1543-2742
DOI:10.1123/ijsnem.2014-0090