Changes in the Qualitative and Quantitative Composition of the Intestinal Microflora in Rats in Experimental Allergic Encephalomyelitis

• Published in: Neuroscience and behavioral physiology 2017-03, Vol.47 (3), p.328-336
• Main Authors: Abdurasulova, I. N., Tarasova, E. A., Matsulevich, A. V., Eliseev, A. V., Ermolenko, E. I., Suvorov, A. N., Klimenko, V. M.
• Format: Article
• Language: English
• Subjects: Antibiotics; Autoimmune diseases; Bacteria; Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Citrobacter; Diet; Disease; Dysbacteriosis; Encephalomyelitis; Escherichia coli; Experimental allergic encephalomyelitis; Faecalibacterium prausnitzii; Gastrointestinal tract; Intestinal microflora; Intestine; Klebsiella; Microbiota; Microorganisms; Multiple sclerosis; Neurobiology; Neurosciences; Pathogenesis; Rats; Spinal cord
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-017-0401-7

We report here a study using a model of multiple sclerosis – experimental allergic encephalomyelitis (EAE) – to investigate changes in the qualitative and quantitative composition of the intestinal microbiota in rats with disease symptoms and with a symptom-free course. When clinical symptoms of EAE were apparent, there were changes in the composition of the microbiota of the gastrointestinal tract, with increases in the numbers of Gram-negative opportunistically pathogenic bacteria: Citrobacter spp., Klebsiella spp., and atypical E. coli . Rats without clinical signs of EAE were also found to have increased contents of Faecalibacterium prausnitzii . The significance of complexes changes in the composition of the intestinal microbiota is discussed, as this provides evidence of prolonged persistence of dysbacteriosis in rats on developing EAE.