Effect of bisphosphonates on root resorption after tooth replantation – a systematic review

Background/Aim Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The anti...

Full description

Saved in:
Bibliographic Details
Published in:Dental traumatology 2017-04, Vol.33 (2), p.77-83
Main Authors: Najeeb, Shariq, Siddiqui, Fahad, Khurshid, Zohaib, Zohaib, Sana, Zafar, Muhammad Sohail, Ansari, Shazia Akbar
Format: Article
Language:English
Subjects:
Alendronic acid
Animal models
Animals
Bisphosphonates
Bone diseases
Dentistry
Diphosphonates - pharmacology
Etidronic acid
Evidence-based medicine
Humans
Osteoporosis
Paget's disease
Periodontics
Quality control
Reviews
Root resorption
Root Resorption - etiology
Root Resorption - prevention & control
Systematic review
Teeth
tooth avulsion
Tooth Replantation
trauma
Zoledronic acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aim Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth. Materials and methods PubMed/MEDLINE, Google Scholar, ISI Web of Knowledge, and Embase databases were searched using keywords ‘bisphosphonate’, ‘replantation’, and ‘tooth’. Quality assessment of each study was carried out. In addition, general characteristics and outcomes of each study were summarized. Results After exclusion of 116 irrelevant articles, 10 animal studies were included in this review. The majority of the studies suggest that surface application of zoledronate or alendronate reduces root resorption of replanted teeth in animal models. Surface treatment with etidronate had no significant effect on root resorption, and intracanal etidronate accelerated resorption. Conclusion Surface application of zoledronate and alendronate reduces root resorption of replanted teeth in animal models. However, the efficacy of intracanal usage of BPs is still debatable.
ISSN:1600-4469
1600-9657
DOI:10.1111/edt.12316