Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2015-05, Vol.29 (5), p.642-651
Main Authors: Cox, Katherine HM, Pipingas, Andrew, Scholey, Andrew B
Format: Article
Language:English
Subjects:
Affect - drug effects
Aged
Aged, 80 and over
Attention - drug effects
Cognition & reasoning
Cognition - drug effects
Curcumin - pharmacology
Dementia
Double-Blind Method
Female
Humans
Lipids
Low density lipoprotein
Male
Memory
Memory, Short-Term - drug effects
Mental disorders
Middle Aged
Neuropsychological Tests
Psychomotor Performance - drug effects
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Summary:Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic (1 and 3 h after single dose following chronic treatment) effects of solid lipid curcumin formulation (400 mg as Longvida®) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60–85. One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. Working memory and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress) were significantly better following chronic treatment. A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures. To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioral effects in humans. Results highlight the need for further investigation of the potential psychological and cognitive benefits of curcumin in an older population.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881114552744