Relationship between CD4 Regulatory T Cells and Anergy In Vivo

Selective suppression of effector CD4 T cell functions is necessary to prevent immune cell-mediated damage to healthy tissues. This appears especially true during pregnancy or in individuals predisposed to autoimmunity. Foxp3 regulatory T (T ) cells and induction of anergy, an acquired state of T ce...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2017-04, Vol.198 (7), p.2527-2533
Main Authors: Kalekar, Lokesh A, Mueller, Daniel L
Format: Article
Language:English
Subjects:
Anergy
Animals
Autoimmunity
CD4 antigen
CD73 antigen
Clonal Anergy - immunology
Damage prevention
Epigenetics
Folic acid
Foxp3 protein
Humans
Immune response
Immunoregulation
Lymphocytes
Lymphocytes T
Pregnancy
T cell receptors
T-Lymphocytes, Regulatory - immunology
Tissues
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Summary:Selective suppression of effector CD4 T cell functions is necessary to prevent immune cell-mediated damage to healthy tissues. This appears especially true during pregnancy or in individuals predisposed to autoimmunity. Foxp3 regulatory T (T ) cells and induction of anergy, an acquired state of T cell functional unresponsiveness in Foxp3 cells, have both been implicated as mechanisms to suppress dangerous immune responses to tissue-restricted self-Ags. Anergic CD4 T cells and T cells share a number of phenotypic and mechanistic traits-including the expression of CD73 and folate receptor 4, and the epigenetic modification of T cell signature genes-and an interesting relationship between these two subsets has recently emerged. In this review, we will compare and contrast these two subsets, as well as explore the role of anergy in the generation of peripheral T cells.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1602031