Pregnancy-associated osteoporosis: a case-control study

Summary The etiology and underlying mechanisms of pregnancy-associated osteoporosis (PAO) are still unknown, since no systematic analyses exist. Our results indicate that PAO is a heterogeneous, rare but severe disease including a substantial number of fractures with a significant delay from first s...

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Bibliographic Details
Published in:Osteoporosis international 2017-04, Vol.28 (4), p.1393-1399
Main Authors: Hadji, P., Boekhoff, J., Hahn, M., Hellmeyer, L., Hars, O., Kyvernitakis, I.
Format: Article
Language:English
Subjects:
Adult
Anthropometry - methods
Case-Control Studies
Children
Endocrinology
Etiology
Female
Fractures
Germany - epidemiology
Humans
Immobilization
Medicine
Medicine & Public Health
Middle Aged
Original Article
Orthopedics
Osteoporosis
Osteoporosis - epidemiology
Osteoporosis - etiology
Osteoporotic Fractures - epidemiology
Osteoporotic Fractures - etiology
Pain
Postpartum
Pregnancy
Pregnancy Complications - epidemiology
Puberty
Rheumatology
Risk Factors
Spine
Vertebrae
Young Adult
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Summary:Summary The etiology and underlying mechanisms of pregnancy-associated osteoporosis (PAO) are still unknown, since no systematic analyses exist. Our results indicate that PAO is a heterogeneous, rare but severe disease including a substantial number of fractures with a significant delay from first symptom to diagnose. Introduction Pregnancy-associated osteoporosis (PAO) is a rare but severe type of premenopausal osteoporosis. Most common symptom includes acute lower back pain due to vertebral fracture predominantly occurring in the last trimester of pregnancy or immediately postpartum. The exact underlining mechanisms and risk factors of PAO are still unknown, and up to date, there are no published systematic analyses. Methods We identified 102 PAO patients and matched them with 102 healthy controls according to age, region, and gravidity to evaluate risk factors in a large and homogenous population of women. Results The baseline characteristics and anthropometric data of the two study groups were similar. Eighty-eight percent of the patients with PAO suffered from one or more fractures with a mean of 3.3 fractures per patient. The most common fracture site was the thoracolumbar spine, whereas 29, 37, 48, and 35% of the patients reported fractures at TH11, TH12, L1, and L2, respectively. PAO patients suffered more frequently from excessive dental problems in childhood ( p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-016-3897-8