MDM2 gene polymorphisms and risk of classic Kaposi’s sarcoma among Iranian patients

A single-nucleotide polymorphism (SNP) in the promoter region of MDM2 (SNP309T>G, rs2279744) has been shown to increase the expression of the MDM2 protein in various cancer types. However, only one study has analyzed the role of the MDM2 polymorphism in the development of Kaposi’s sarcoma (KS). T...

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Bibliographic Details
Published in:Medical microbiology and immunology 2017-04, Vol.206 (2), p.157-163
Main Authors: Varmazyar, Sajad, Marashi, Sayed Mahdi, Shoja, Zabihollah, Tornesello, Maria Lina, Buonaguro, Franco M., Shahmahmoodi, Shohreh, Safaie-Naraghi, Zahra, Jalilvand, Somayeh
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Biomedical and Life Sciences
Biomedicine
Cancer
Case-Control Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genome, Viral
Genotype
Genotype & phenotype
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - immunology
Humans
Immunology
Iran - epidemiology
Male
Medical Microbiology
Middle Aged
Odds Ratio
Original Investigation
Polymorphism
Polymorphism, Single Nucleotide
Prevalence
Proto-Oncogene Proteins c-mdm2 - genetics
Risk
Risk factors
Sarcoma, Kaposi - epidemiology
Sarcoma, Kaposi - genetics
Sarcoma, Kaposi - virology
Virology
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Summary:A single-nucleotide polymorphism (SNP) in the promoter region of MDM2 (SNP309T>G, rs2279744) has been shown to increase the expression of the MDM2 protein in various cancer types. However, only one study has analyzed the role of the MDM2 polymorphism in the development of Kaposi’s sarcoma (KS). The association of MDM2 SNP309 with classic KS risk was evaluated in 79 Iranian patients with classic KS and 123 healthy controls. The MDM2 SNP309 was genotyped using PCR and restriction fragment length polymorphism methods. No significant correlation was found between the SNP309 polymorphism in MDM2 promoter and classic KS risk. There was no significant correlation between gender and disease stage. However, a significant association was found between SNP309 GG genotype and younger age (≤50 years) (odds ratio 9.5, 95% confidence intervals 1.5–60, p  = 0.03). Our findings support no major role for the MDM2 SNP309 in KS development although it might influence the clinical outcome of KS in younger patients.
ISSN:0300-8584
1432-1831
DOI:10.1007/s00430-016-0491-9