Posttraumatic stress disorder symptomatology in the course of allogeneic HSCT: a prospective study

Purpose Despite the life-threatening character of allogeneic hematopoietic stem cell transplantation (allogeneic HSCT), very few longitudinal research exists on posttraumatic stress disorder (PTSD) symptomatology in this patient group. We investigated prevalence, temporal course and predictors of PT...

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Bibliographic Details
Published in:Journal of cancer survivorship 2017-04, Vol.11 (2), p.203-210
Main Authors: Esser, Peter, Kuba, Katharina, Scherwath, Angela, Schirmer, Lena, Schulz-Kindermann, Frank, Dinkel, Andreas, Balck, Friedrich, Koch, Uwe, Kröger, Nicolaus, Götze, Heide, Mehnert, Anja
Format: Article
Language:English
Subjects:
Aged
Cancer
Female
Health Informatics
Health Promotion and Disease Prevention
Hematopoietic Stem Cell Transplantation - methods
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Post traumatic stress disorder
Prevalence
Primary Care Medicine
Prospective Studies
Public Health
Quality of Life Research
Risk Factors
Stem cells
Stress Disorders, Post-Traumatic - diagnosis
Studies
Survivors
Transplantation Conditioning - methods
Transplantation, Homologous
Transplants & implants
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Summary:Purpose Despite the life-threatening character of allogeneic hematopoietic stem cell transplantation (allogeneic HSCT), very few longitudinal research exists on posttraumatic stress disorder (PTSD) symptomatology in this patient group. We investigated prevalence, temporal course and predictors of PTSD symptomatology in this population. Methods Patients were assessed before conditioning (T0), 100 days (T1), and 12 months after HSCT (T2). PTSD symptomatology was measured with the PTSD Checklist—Civilian Version. We conducted multilevel modeling and multiple regression analyses. Results Two hundred thirty-nine patients participated at baseline, 150 at T1, and 102 at T2. Up to 15 % met the criteria for PTSD at least once during the course of assessment. Fifty-two percent showed diagnostic relevant levels of intrusion, 30 % of avoidance, and 33 % of arousal at least once. Apart from arousal, which increased between T0 and T1 ( γ  = 0.56, p  = 0.03), no other severity score significantly differed between time points. Being impaired by pain ( γ  = 2.89, p  
ISSN:1932-2259
1932-2267
DOI:10.1007/s11764-016-0579-7