Behavioral methods for the functional assessment of hair cells in zebrafish

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers of medicine 2017-06, Vol.11 (2), p.178-190
Main Authors: Yang, Qin, Sun, Peng, Chen, Shi, Li, Hongzhe, Chen, Fangyi
Format: Article
Language:English
Subjects:
Animals
auditory
behavior
Behavior Rating Scale
Behavior, Animal
Hair Cells, Auditory - physiology
High-Throughput Screening Assays
Humans
Medicine
Medicine & Public Health
Models, Animal
Reflex, Startle - physiology
Review
rheotaxis
startle response
vestibular-ocular reflex
zebrafish ( Danio rerio)
Zebrafish - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-017-0507-x