The duality of macrophage function in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia and, in some patients, is accompanied by resistance to both chemotherapeutics and immunotherapeutics. In this review we will discuss the role of tumour associated macrophages (TAMs) in promoting CLL cell survival and resistance t...

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Published in:Biochimica et biophysica acta. Reviews on cancer 2017-08, Vol.1868 (1), p.176-182
Main Authors: Chen, Y.C.E., Mapp, S., Blumenthal, A., Burgess, M.L., Mazzieri, R., Mattarollo, S.R., Mollee, P., Gill, D., Saunders, N.A.
Format: Article
Language:English
Subjects:
Animals
Cell Survival - physiology
Drug Resistance, Neoplasm - physiology
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Macrophages - pathology
T-Lymphocytes - pathology
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Summary:Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia and, in some patients, is accompanied by resistance to both chemotherapeutics and immunotherapeutics. In this review we will discuss the role of tumour associated macrophages (TAMs) in promoting CLL cell survival and resistance to immunotherapeutics. In addition, we will discuss mechanisms by which TAMs suppress T-cell mediated antitumour responses. Thus, targeting macrophages could be used to i) reduce the leukaemic burden via the induction of T-cell-mediated antitumour responses, ii) to reduce pro-survival signalling and enhance response to conventional chemotherapeutics or iii) enhance the response to therapeutic antibodies in current clinical use.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2017.03.006