A systematic review of genetic syndromes with obesity

Summary Syndromic monogenic obesity typically follows Mendelian patterns of inheritance and involves the co‐presentation of other characteristics, such as mental retardation, dysmorphic features and organ‐specific abnormalities. Previous reviews on obesity have reported 20 to 30 syndromes but no sys...

Full description

Saved in:
Bibliographic Details
Published in:Obesity reviews 2017-06, Vol.18 (6), p.603-634
Main Authors: Kaur, Y., Souza, R. J., Gibson, W. T., Meyre, D.
Format: Article
Language:English
Subjects:
Abnormalities
Biomedical Research - trends
Chromosome Disorders - complications
Chromosome Disorders - genetics
Classification
disease heterogeneity
Disorders
Genetic Diseases, Inborn - complications
Genetic Diseases, Inborn - genetics
genetic elucidation
Genetic Markers
Genetic Predisposition to Disease
Heredity
Humans
Literature reviews
Naming
Obesity
Obesity - complications
Obesity - genetics
quality of evidence
Reviews
Syndrome
syndromic obesity
Systematic review
Terminology as Topic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Syndromic monogenic obesity typically follows Mendelian patterns of inheritance and involves the co‐presentation of other characteristics, such as mental retardation, dysmorphic features and organ‐specific abnormalities. Previous reviews on obesity have reported 20 to 30 syndromes but no systematic review has yet been conducted on syndromic obesity. We searched seven databases using terms such as ‘obesity’, ‘syndrome’ and ‘gene’ to conduct a systematic review of literature on syndromic obesity. Our literature search identified 13,719 references. After and full‐text review, 119 relevant papers were eligible, and 42 papers were identified through additional searches. Our analysis of these 161 papers found that 79 obesity syndromes have been reported in literature. Of the 79 syndromes, 19 have been fully genetically elucidated, 11 have been partially elucidated, 27 have been mapped to a chromosomal region and for the remaining 22, neither the gene(s) nor the chromosomal location(s) have yet been identified. Interestingly, 54.4% of the syndromes have not been assigned a name, whereas 13.9% have more than one name. We report on organizational inconsistencies (e.g. naming discrepancies and syndrome classification) and provide suggestions for improvements. Overall, this review illustrates the need for increased clinical and genetic research on syndromes with obesity.
ISSN:1467-7881
1467-789X
DOI:10.1111/obr.12531