DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells – Implications for age-related macular degeneration (AMD)

Highlights • AMD is a major and emerging cause of vision loss in the elderly. • reactive oxygen species induce DNA damage, which can contribute to AMD. • autophagy may be involved in AMD pathogenesis. • autophagy and DNA damage response can interplay contributing to AMD development.

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Bibliographic Details
Published in:Ageing research reviews 2017-07, Vol.36, p.64-77
Main Authors: Hyttinen, Juha M.T, Błasiak, Janusz, Niittykoski, Minna, Kinnunen, Kati, Kauppinen, Anu, Salminen, Antero, Kaarniranta, Kai
Format: Article
Language:English
Subjects:
Animals
Autophagy - physiology
DNA Damage - physiology
Humans
Internal Medicine
Lipofuscin - metabolism
Macular Degeneration - metabolism
Macular Degeneration - pathology
Mitochondria - metabolism
Mitochondria - pathology
Neurology
Reactive Oxygen Species - metabolism
Retina - metabolism
Retina - pathology
Retinal Pigment Epithelium - metabolism
Retinal Pigment Epithelium - pathology
Retinal Pigments - metabolism
Signal Transduction
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Description
Summary:Highlights • AMD is a major and emerging cause of vision loss in the elderly. • reactive oxygen species induce DNA damage, which can contribute to AMD. • autophagy may be involved in AMD pathogenesis. • autophagy and DNA damage response can interplay contributing to AMD development.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2017.03.006