A new proposition for the screening of platelet function defects using an hematology analyzer

Abstract In this paper we suggest a new method for the screening of congenital thrombopathies using an hematology analyzer. This method is an improvement of the platelet count ratio principle which uses an impedance counter to search a decrease of the free platelet count after adding platelet agonis...

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Bibliographic Details
Published in:Medical hypotheses 2017-04, Vol.101, p.28-29
Main Authors: Bennaoum, Mohammed Nazim, Lazreg, Hassiba, Adda, Affaf, Hammadi, Mohamed
Format: Article
Language:English
Subjects:
ADVIA 2120i
Blood Platelets - physiology
Hematologic Diseases - blood
Hematologic Diseases - diagnosis
Hematology - instrumentation
Hematology - methods
Humans
Internal Medicine
Models, Theoretical
Platelet Activation
Platelet Count
Platelet defects
Platelet Function Tests
ROC Curve
Screening method
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Summary:Abstract In this paper we suggest a new method for the screening of congenital thrombopathies using an hematology analyzer. This method is an improvement of the platelet count ratio principle which uses an impedance counter to search a decrease of the free platelet count after adding platelet agonist to whole blood. We suggest using novel platelet parameters provided by an optical hematology analyzer such as ADVIA 2120i (Siemens Healthcare Diagnostics) to search morphological and structural changes of platelet that are supposed reflecting platelet activation in normal platelets after addition of an agonist.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2017.02.005