Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine

Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profi...

Full description

Saved in:
Bibliographic Details
Published in:Biology of reproduction 2003-08, Vol.69 (2), p.430-436
Main Authors: Archer, G S, Dindot, S, Friend, TH, Walker, S, Zaunbrecher, G, Lawhorn, B, Piedrahita, JA
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 436
container_issue 2
container_start_page 430
container_title Biology of reproduction
container_volume 69
creator Archer, G S
Dindot, S
Friend, TH
Walker, S
Zaunbrecher, G
Lawhorn, B
Piedrahita, JA
description Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.
doi_str_mv 10.1043/0006-3363(2003)069(0430:HPAEVI)2.0.CO;2
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_18821795</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18821795</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_188217953</originalsourceid><addsrcrecordid>eNqNirsKwjAUQDMo-PyHTKKD9SbR-lqUUqmTBcVVQr3qlZjUpiL-vQ7i7HQ4h8PYQEAgYKgGABD2lQpVVwKoHoTT7ifDLEmX8X7dkwEE0WYuK6z-O2us4f0VQAyVVHW2SAgLXWQXyrTh6QWtK185ZVzbI49zOqPF8qN7XZAuyVlOlkfGWTzy7ZMstlj1pI3H9pdN1lnFuyjp54W7P9CXhxv5DI3RFt3DH8RkIsV4OlJ_j2-V-kWM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18821795</pqid></control><display><type>article</type><title>Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine</title><source>Oxford Journals Online</source><creator>Archer, G S ; Dindot, S ; Friend, TH ; Walker, S ; Zaunbrecher, G ; Lawhorn, B ; Piedrahita, JA</creator><creatorcontrib>Archer, G S ; Dindot, S ; Friend, TH ; Walker, S ; Zaunbrecher, G ; Lawhorn, B ; Piedrahita, JA</creatorcontrib><description>Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.</description><identifier>ISSN: 0006-3363</identifier><identifier>DOI: 10.1043/0006-3363(2003)069(0430:HPAEVI)2.0.CO;2</identifier><language>eng</language><ispartof>Biology of reproduction, 2003-08, Vol.69 (2), p.430-436</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Archer, G S</creatorcontrib><creatorcontrib>Dindot, S</creatorcontrib><creatorcontrib>Friend, TH</creatorcontrib><creatorcontrib>Walker, S</creatorcontrib><creatorcontrib>Zaunbrecher, G</creatorcontrib><creatorcontrib>Lawhorn, B</creatorcontrib><creatorcontrib>Piedrahita, JA</creatorcontrib><title>Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine</title><title>Biology of reproduction</title><description>Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.</description><issn>0006-3363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNirsKwjAUQDMo-PyHTKKD9SbR-lqUUqmTBcVVQr3qlZjUpiL-vQ7i7HQ4h8PYQEAgYKgGABD2lQpVVwKoHoTT7ifDLEmX8X7dkwEE0WYuK6z-O2us4f0VQAyVVHW2SAgLXWQXyrTh6QWtK185ZVzbI49zOqPF8qN7XZAuyVlOlkfGWTzy7ZMstlj1pI3H9pdN1lnFuyjp54W7P9CXhxv5DI3RFt3DH8RkIsV4OlJ_j2-V-kWM</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Archer, G S</creator><creator>Dindot, S</creator><creator>Friend, TH</creator><creator>Walker, S</creator><creator>Zaunbrecher, G</creator><creator>Lawhorn, B</creator><creator>Piedrahita, JA</creator><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20030801</creationdate><title>Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine</title><author>Archer, G S ; Dindot, S ; Friend, TH ; Walker, S ; Zaunbrecher, G ; Lawhorn, B ; Piedrahita, JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_188217953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Archer, G S</creatorcontrib><creatorcontrib>Dindot, S</creatorcontrib><creatorcontrib>Friend, TH</creatorcontrib><creatorcontrib>Walker, S</creatorcontrib><creatorcontrib>Zaunbrecher, G</creatorcontrib><creatorcontrib>Lawhorn, B</creatorcontrib><creatorcontrib>Piedrahita, JA</creatorcontrib><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Archer, G S</au><au>Dindot, S</au><au>Friend, TH</au><au>Walker, S</au><au>Zaunbrecher, G</au><au>Lawhorn, B</au><au>Piedrahita, JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine</atitle><jtitle>Biology of reproduction</jtitle><date>2003-08-01</date><risdate>2003</risdate><volume>69</volume><issue>2</issue><spage>430</spage><epage>436</epage><pages>430-436</pages><issn>0006-3363</issn><abstract>Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.</abstract><doi>10.1043/0006-3363(2003)069(0430:HPAEVI)2.0.CO;2</doi></addata></record>
fulltext fulltext
identifier ISSN: 0006-3363
ispartof Biology of reproduction, 2003-08, Vol.69 (2), p.430-436
issn 0006-3363
language eng
recordid cdi_proquest_miscellaneous_18821795
source Oxford Journals Online
title Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T14%3A23%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hierarchical%20Phenotypic%20and%20Epigenetic%20Variation%20in%20Cloned%20Swine&rft.jtitle=Biology%20of%20reproduction&rft.au=Archer,%20G%20S&rft.date=2003-08-01&rft.volume=69&rft.issue=2&rft.spage=430&rft.epage=436&rft.pages=430-436&rft.issn=0006-3363&rft_id=info:doi/10.1043/0006-3363(2003)069(0430:HPAEVI)2.0.CO;2&rft_dat=%3Cproquest%3E18821795%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_188217953%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18821795&rft_id=info:pmid/&rfr_iscdi=true