Redox status alterations during the competitive season in élite soccer players: focus on peripheral leukocyte-derived ROS

It is well known that exercise training can deeply affect redox homeostasis by enhancing antioxidant defenses. However, exhaustive exercise can induce excessive reactive oxygen species (ROS) production, leading to oxidative stress-related tissue injury and impaired muscle contractility. Hence, ROS r...

Full description

Saved in:
Bibliographic Details
Published in:Internal and emergency medicine 2017-09, Vol.12 (6), p.777-788
Main Authors: Becatti, Matteo, Mannucci, Amanda, Barygina, Victoria, Mascherini, Gabriele, Emmi, Giacomo, Silvestri, Elena, Wright, Daniel, Taddei, Niccolò, Galanti, Giorgio, Fiorillo, Claudia
Format: Article
Language:English
Subjects:
Athletes
Contractility
Exercise
Homeostasis
Im - Original
Internal Medicine
Medicine
Medicine & Public Health
Mitochondria
Muscle contraction
Myoglobins
NAD(P)H oxidase
Oxidants
Oxidative stress
Oxidizing agents
Reactive oxygen species
Revisions
Seasons
Soccer
Stress
Subpopulations
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is well known that exercise training can deeply affect redox homeostasis by enhancing antioxidant defenses. However, exhaustive exercise can induce excessive reactive oxygen species (ROS) production, leading to oxidative stress-related tissue injury and impaired muscle contractility. Hence, ROS represent important signaling molecules whose level has to be maintained to preserve normal cellular function, but which can also accumulate in response to repetitive muscle contraction. In fact, low levels of oxidants have been suggested to be essential for muscle contraction. Both aerobic and anaerobic exercise induce ROS production from several sources (mitochondria, NADPH oxidases and xanthine oxidases); however, the exact mechanisms underlying exercise-induced oxidative stress remain undefined. Professional athletes show a high risk for oxidative stress, and consequently muscle injury or decreased performance. Based on this background, we investigated leukocyte redox homeostasis alterations during the soccer season in élite soccer players. Overall blood redox status was investigated in twenty-seven male soccer players from primary division (Italian “Serie A” team) at four critical time points during the soccer season: T0: just before the first team training session; T1: at the beginning of the season; T2: in the middle of the season and T3: at the end of the season. The main markers of muscular damage (CK, myoglobin, LDH), assessed by standard routine methods, are significantly altered at the considered time points (T0 vs T1 P  
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-017-1653-5