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Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma
Purpose The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of...
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| Published in: | European spine journal 2017-05, Vol.26 (Suppl 1), p.225-228 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c415t-cad34aee9f9bbc9abe8a64535b606479d495781ae3a2289981ba3c439d9f129e3 |
| container_end_page | 228 |
| container_issue | Suppl 1 |
| container_start_page | 225 |
| container_title | European spine journal |
| container_volume | 26 |
| creator | Di Felice, Francesca Zaina, Fabio Donzelli, Sabrina Negrini, Stefano |
| description | Purpose
The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of a girl with spontaneous complete healing.
Methods ad results
A 3-year-old girl was referred for nighttime back pain, with no fever and no neurologic signs. Within a few days, she developed sudden painful restriction of all spine movements. X-ray and computed tomography (CT) of the spine showed reduced T7 vertebral body height (vertebra plana).The patient underwent T7 curettage and the histopathological exam was suggestive of LCH. Two additional skull lesions were found and therefore she underwent chemotherapy. After 7 years of follow-up, total vertebral reconstruction was observed.
Conclusions
Despite the rarity of the condition and despite the rarity of vertebral body lesion resolution, total vertebral body reconstruction was observed over a 7-year period. Long-term follow-up is necessary for a better understanding of the final outcome of patients with EG. |
| doi_str_mv | 10.1007/s00586-017-5063-1 |
| format | article |
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The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of a girl with spontaneous complete healing.
Methods ad results
A 3-year-old girl was referred for nighttime back pain, with no fever and no neurologic signs. Within a few days, she developed sudden painful restriction of all spine movements. X-ray and computed tomography (CT) of the spine showed reduced T7 vertebral body height (vertebra plana).The patient underwent T7 curettage and the histopathological exam was suggestive of LCH. Two additional skull lesions were found and therefore she underwent chemotherapy. After 7 years of follow-up, total vertebral reconstruction was observed.
Conclusions
Despite the rarity of the condition and despite the rarity of vertebral body lesion resolution, total vertebral body reconstruction was observed over a 7-year period. Long-term follow-up is necessary for a better understanding of the final outcome of patients with EG.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-017-5063-1</identifier><identifier>PMID: 28361364</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Back Pain - etiology ; Body height ; Case Report ; Case reports ; Cell proliferation ; Chemotherapy ; Child, Preschool ; Computed tomography ; Curettage ; Curettage - methods ; Eosinophilic Granuloma - complications ; Eosinophilic Granuloma - diagnostic imaging ; Eosinophilic Granuloma - surgery ; Female ; Fever ; Fractures, Spontaneous - etiology ; Granuloma ; Granulomas ; Histiocytosis ; Humans ; Langerhans cell histiocytosis ; Langerhans cells ; Leukocytes (eosinophilic) ; Medicine ; Medicine & Public Health ; Neurosurgery ; Nighttime ; Pain ; Radiography ; Regeneration ; Skeleton ; Skull ; Spinal Diseases - complications ; Spinal Diseases - diagnostic imaging ; Spinal Diseases - surgery ; Spinal Fractures - etiology ; Spine ; Surgical Orthopedics ; Thoracic Vertebrae - diagnostic imaging ; Thoracic Vertebrae - physiology ; Thoracic Vertebrae - surgery ; Tomography, X-Ray Computed ; Vertebrae</subject><ispartof>European spine journal, 2017-05, Vol.26 (Suppl 1), p.225-228</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>European Spine Journal is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-cad34aee9f9bbc9abe8a64535b606479d495781ae3a2289981ba3c439d9f129e3</citedby><cites>FETCH-LOGICAL-c415t-cad34aee9f9bbc9abe8a64535b606479d495781ae3a2289981ba3c439d9f129e3</cites><orcidid>0000-0002-9553-4499</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28361364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Felice, Francesca</creatorcontrib><creatorcontrib>Zaina, Fabio</creatorcontrib><creatorcontrib>Donzelli, Sabrina</creatorcontrib><creatorcontrib>Negrini, Stefano</creatorcontrib><title>Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of a girl with spontaneous complete healing.
Methods ad results
A 3-year-old girl was referred for nighttime back pain, with no fever and no neurologic signs. Within a few days, she developed sudden painful restriction of all spine movements. X-ray and computed tomography (CT) of the spine showed reduced T7 vertebral body height (vertebra plana).The patient underwent T7 curettage and the histopathological exam was suggestive of LCH. Two additional skull lesions were found and therefore she underwent chemotherapy. After 7 years of follow-up, total vertebral reconstruction was observed.
Conclusions
Despite the rarity of the condition and despite the rarity of vertebral body lesion resolution, total vertebral body reconstruction was observed over a 7-year period. Long-term follow-up is necessary for a better understanding of the final outcome of patients with EG.</description><subject>Back Pain - etiology</subject><subject>Body height</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Cell proliferation</subject><subject>Chemotherapy</subject><subject>Child, Preschool</subject><subject>Computed tomography</subject><subject>Curettage</subject><subject>Curettage - methods</subject><subject>Eosinophilic Granuloma - complications</subject><subject>Eosinophilic Granuloma - diagnostic imaging</subject><subject>Eosinophilic Granuloma - surgery</subject><subject>Female</subject><subject>Fever</subject><subject>Fractures, Spontaneous - etiology</subject><subject>Granuloma</subject><subject>Granulomas</subject><subject>Histiocytosis</subject><subject>Humans</subject><subject>Langerhans cell histiocytosis</subject><subject>Langerhans cells</subject><subject>Leukocytes (eosinophilic)</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Nighttime</subject><subject>Pain</subject><subject>Radiography</subject><subject>Regeneration</subject><subject>Skeleton</subject><subject>Skull</subject><subject>Spinal Diseases - complications</subject><subject>Spinal Diseases - diagnostic imaging</subject><subject>Spinal Diseases - surgery</subject><subject>Spinal Fractures - etiology</subject><subject>Spine</subject><subject>Surgical Orthopedics</subject><subject>Thoracic Vertebrae - diagnostic imaging</subject><subject>Thoracic Vertebrae - physiology</subject><subject>Thoracic Vertebrae - surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Vertebrae</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1jAQhS0Eoj-FB2CDLLFhE_DEjmMvUcVNqtRFYW1NnElIldjBdpD69k1JQQiJ1SzmO2cuh7GXIN6CEO27LERjdCWgrRqhZQWP2AmUrCthZf2YnYRVotIt2DP2LOcbIaCxQj9lZ7WRGqRWJxav1xgKBopb5hh67uOyzlSIJxopUMIyxcDjwJH_pFSoS8jXGQNyHAolnrc0Th5n7rdEpeBIv-DAKeYpxPX7NE-ejwnDNscFn7MnA86ZXjzUc_bt44evF5-ry6tPXy7eX1ZeQVMqj71USGQH23XeYkcGtWpk02mhVWt7ZZvWAJLEujbWGuhQeiVtbweoLclz9ubwXVP8sVEubpmyp3k-TnVgjITWKKt29PU_6E3cUti3c2CFatvagNkpOCifYs6JBremacF060C4-zTckYbb03D3aTjYNa8enLduof6P4vf7d6A-gLy3wkjpr9H_db0DtW6WMw</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Di Felice, Francesca</creator><creator>Zaina, Fabio</creator><creator>Donzelli, Sabrina</creator><creator>Negrini, Stefano</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9553-4499</orcidid></search><sort><creationdate>20170501</creationdate><title>Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma</title><author>Di Felice, Francesca ; Zaina, Fabio ; Donzelli, Sabrina ; Negrini, Stefano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-cad34aee9f9bbc9abe8a64535b606479d495781ae3a2289981ba3c439d9f129e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Back Pain - etiology</topic><topic>Body height</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Cell proliferation</topic><topic>Chemotherapy</topic><topic>Child, Preschool</topic><topic>Computed tomography</topic><topic>Curettage</topic><topic>Curettage - methods</topic><topic>Eosinophilic Granuloma - complications</topic><topic>Eosinophilic Granuloma - diagnostic imaging</topic><topic>Eosinophilic Granuloma - surgery</topic><topic>Female</topic><topic>Fever</topic><topic>Fractures, Spontaneous - etiology</topic><topic>Granuloma</topic><topic>Granulomas</topic><topic>Histiocytosis</topic><topic>Humans</topic><topic>Langerhans cell histiocytosis</topic><topic>Langerhans cells</topic><topic>Leukocytes (eosinophilic)</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Nighttime</topic><topic>Pain</topic><topic>Radiography</topic><topic>Regeneration</topic><topic>Skeleton</topic><topic>Skull</topic><topic>Spinal Diseases - complications</topic><topic>Spinal Diseases - diagnostic imaging</topic><topic>Spinal Diseases - surgery</topic><topic>Spinal Fractures - etiology</topic><topic>Spine</topic><topic>Surgical Orthopedics</topic><topic>Thoracic Vertebrae - diagnostic imaging</topic><topic>Thoracic Vertebrae - physiology</topic><topic>Thoracic Vertebrae - surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Felice, Francesca</creatorcontrib><creatorcontrib>Zaina, Fabio</creatorcontrib><creatorcontrib>Donzelli, Sabrina</creatorcontrib><creatorcontrib>Negrini, Stefano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Felice, Francesca</au><au>Zaina, Fabio</au><au>Donzelli, Sabrina</au><au>Negrini, Stefano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>26</volume><issue>Suppl 1</issue><spage>225</spage><epage>228</epage><pages>225-228</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of a girl with spontaneous complete healing.
Methods ad results
A 3-year-old girl was referred for nighttime back pain, with no fever and no neurologic signs. Within a few days, she developed sudden painful restriction of all spine movements. X-ray and computed tomography (CT) of the spine showed reduced T7 vertebral body height (vertebra plana).The patient underwent T7 curettage and the histopathological exam was suggestive of LCH. Two additional skull lesions were found and therefore she underwent chemotherapy. After 7 years of follow-up, total vertebral reconstruction was observed.
Conclusions
Despite the rarity of the condition and despite the rarity of vertebral body lesion resolution, total vertebral body reconstruction was observed over a 7-year period. Long-term follow-up is necessary for a better understanding of the final outcome of patients with EG.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28361364</pmid><doi>10.1007/s00586-017-5063-1</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9553-4499</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Back Pain - etiology Body height Case Report Case reports Cell proliferation Chemotherapy Child, Preschool Computed tomography Curettage Curettage - methods Eosinophilic Granuloma - complications Eosinophilic Granuloma - diagnostic imaging Eosinophilic Granuloma - surgery Female Fever Fractures, Spontaneous - etiology Granuloma Granulomas Histiocytosis Humans Langerhans cell histiocytosis Langerhans cells Leukocytes (eosinophilic) Medicine Medicine & Public Health Neurosurgery Nighttime Pain Radiography Regeneration Skeleton Skull Spinal Diseases - complications Spinal Diseases - diagnostic imaging Spinal Diseases - surgery Spinal Fractures - etiology Spine Surgical Orthopedics Thoracic Vertebrae - diagnostic imaging Thoracic Vertebrae - physiology Thoracic Vertebrae - surgery Tomography, X-Ray Computed Vertebrae |
| title | Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma |
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