Correction of Abnormalities Provoked by Long-Term Alcoholization with Hypoxic-Hyperoxic Training

Free radical oxidation in the liver and skeletal muscles as well as stress behavior were examined in rats subjected to a gradual long-term alcoholization with elevated ethanol content from 10 to 40% followed by correction of alcohol-induced disturbances with hypoxic-hyperoxic training. The elevated...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.624-628
Main Authors: Sazontova, T. G., Stryapko, N. V., Arkhipenko, Yu. V.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Alcoholism - metabolism
Animals
Antioxidants (Nutrients)
Anxiety
Anxiety - chemically induced
Anxiety - metabolism
Biomedical and Life Sciences
Biomedicine
Catalase - metabolism
Cell Biology
Cell Hypoxia
Enzymes
Ethanol
Ethanol - adverse effects
Free radicals
Health aspects
Hyperoxia
Hyperoxia - metabolism
Hypoxia
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Liver - enzymology
Male
Motor task performance
Oxidative Stress
Pathology
Protective Factors
Rats, Wistar
Reactive Oxygen Species
Risk-Taking
Rodents
Skeletal muscle
Superoxide Dismutase - metabolism
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Summary:Free radical oxidation in the liver and skeletal muscles as well as stress behavior were examined in rats subjected to a gradual long-term alcoholization with elevated ethanol content from 10 to 40% followed by correction of alcohol-induced disturbances with hypoxic-hyperoxic training. The elevated plus-maze test revealed increased anxiety and appearance of risky behavior in alcoholized rats in the absence of changes in motor and orientation activity. In the liver and skeletal muscles of alcoholized rats, free radical oxidation processes were decompensated despite activation of antioxidant enzymes. Adaptation to intermittent hypoxia-hyperoxia during last two weeks of alcoholization exerted a protective effect against ethanol-induced oxidative stress: reduced anxious and risk behavior, normalized tissue tolerance of free radical oxidation processes, and restored the level of protective proteins.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3672-7