Anxiolytic Properties of Trimetazidine in Experimental Models of Increased Anxiety

Effect of trimetazidine (20 and 30 mg/kg) on elevated plus maze behavior of rodents was assessed in the genetic and pharmacological anxiety models. Single intraperitoneal injection of trimetazidine in a dose of 20 mg/kg prevented anxiety development in highly emotional male BALB/c mice and increased...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.643-646
Main Authors: Kolik, L. G., Nadorova, A. V., Stolyaruk, V. N., Miroshkina, I. A., Tsorin, I. B., Kryzhanovskii, S. A.
Format: Article
Language:English
Subjects:
Alcoholism - psychology
Analysis
Animal models
Animals
Animals, Outbred Strains
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
Antianxiety agents
Anxiety
Anxiety - drug therapy
Benzimidazoles - pharmacology
Benzimidazoles - therapeutic use
Benzodiazepines
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug Evaluation, Preclinical
Emotions
Ethanol
Ethanol - adverse effects
Internal Medicine
Laboratory Medicine
Locomotor activity
Male
Mice, Inbred BALB C
Morpholines - pharmacology
Morpholines - therapeutic use
Pathology
Rats
Rodents
Substance Withdrawal Syndrome - drug therapy
Substance Withdrawal Syndrome - psychology
Trimetazidine
Trimetazidine - pharmacology
Trimetazidine - therapeutic use
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Summary:Effect of trimetazidine (20 and 30 mg/kg) on elevated plus maze behavior of rodents was assessed in the genetic and pharmacological anxiety models. Single intraperitoneal injection of trimetazidine in a dose of 20 mg/kg prevented anxiety development in highly emotional male BALB/c mice and increased the time spent in open arms of the maze. In outbred male rats receiving 10% ethanol solution for 20 weeks, trimetazidine administered intraperitoneally in a dose of 20 mg/kg for 28 days abolished ethanol withdrawal-induced anxiogenesis developed against the background of 4-week alcohol deprivation: it increased the time spent in open arms, the number of entries into open arms, and total locomotor activity in the maze. Anxiolytic properties of trimetazidine were not inferior to those of the non-benzodiazepine anxiolytic Afobazole (fabomotizole) in acute and chronic administration.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3677-2