Quorum quenching properties of Actinobacteria isolated from Malaysian tropical soils

In this study, a total of 147 soil actinobacterial strains were screened for their ability to inhibit response of Chromobacterium violaceum CV026 to short chain N -acyl homoserine lactone (AHL) which is a quorum sensing molecule. Of these, three actinobacterial strains showed positive for violacein...

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Bibliographic Details
Published in:Archives of microbiology 2017-08, Vol.199 (6), p.897-906
Main Authors: Devaraj, Kavimalar, Tan, Geok Yuan Annie, Chan, Kok-Gan
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - metabolism
Actinobacteria - classification
Actinobacteria - genetics
Actinobacteria - isolation & purification
Actinobacteria - physiology
Bacteria
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cell Biology
Chromobacterium - physiology
Detection
Ecology
Gene sequencing
Life Sciences
Malaysia
Microbial Ecology
Microbiology
N-Acyl homoserine lactone
Original Paper
Phylogeny
Pseudomonas aeruginosa
Pseudomonas aeruginosa - physiology
Pyocyanin
Pyocyanine
Quorum Sensing
Rhodococcus
rRNA 16S
Soil Microbiology
Strains (organisms)
Swarming
Tropical environments
Tropical soils
Violacein
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Summary:In this study, a total of 147 soil actinobacterial strains were screened for their ability to inhibit response of Chromobacterium violaceum CV026 to short chain N -acyl homoserine lactone (AHL) which is a quorum sensing molecule. Of these, three actinobacterial strains showed positive for violacein inhibition. We further tested these strains for the inhibition of Pseudomonas aeruginosa PAO1 quorum sensing-regulated phenotypes, namely, swarming and pyocyanin production. The three strains were found to inhibit at least one of the quorum sensing-regulated phenotypes of PAO1. Phylogenetic analysis of the 16S rRNA gene sequences indicated that these strains belong to the genera Micromonospora, Rhodococcus and Streptomyces . This is the first report presenting quorum quenching activity by a species of the genus Micromonospora . Our data suggest that Actinobacteria may be a rich source of active compounds that can act against bacterial quorum sensing system.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-017-1371-4