The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin

In this work, we studied the effects of kaurenoic acid, a diterpene isolated from the oleo-resin of Copaifera langsdorffii in developing sea urchin ( Lytechinus variegatus) embryos, on tumor cell growth in microculture tetrazolium (MTT) test and on mouse and human erythrocytes in hemolysis assay. Co...

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Bibliographic Details
Published in:Toxicon (Oxford) 2002-08, Vol.40 (8), p.1231-1234
Main Authors: Costa-Lotufo, L.V., Cunha, G.M.A., Farias, P.A.M., Viana, G.S.B., Cunha, K.M.A., Pessoa, C., Moraes, M.O., Silveira, E.R., Gramosa, N.V., Rao, V.S.N.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Survival - drug effects
Copaifera langsdorffii
Cytotoxicity
Cytotoxins - chemistry
Cytotoxins - toxicity
Diterpenes - chemistry
Diterpenes - toxicity
Embryo, Nonmammalian
embryotoxicity
Erythrocyte hemolysis
Erythrocytes - drug effects
General pharmacology
Hemolysis - drug effects
Humans
In Vitro Techniques
Kaurenoic acid
Lytechinus variegatus
Magnetic Resonance Spectroscopy
Marine
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant diterpene
Plants, Medicinal - chemistry
Resins, Plant - chemistry
Sea urchin embryos
Sea Urchins - physiology
Teratogens - chemistry
Teratogens - toxicity
Tumor cells
Tumor Cells, Cultured
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Summary:In this work, we studied the effects of kaurenoic acid, a diterpene isolated from the oleo-resin of Copaifera langsdorffii in developing sea urchin ( Lytechinus variegatus) embryos, on tumor cell growth in microculture tetrazolium (MTT) test and on mouse and human erythrocytes in hemolysis assay. Continuous exposure of embryos to kaurenoic acid starting immediately after fertilization inhibited the first cleavage (IC 50: 84.2 μM) and progressively induced embryo destruction (IC 50: 44.7 μM and
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(02)00128-9