No evidence of increased ocular involvement in candidemic patients initially treated with echinocandins

Abstract Candins are commonly used as initial therapy in patients with candidemia and are known to diffuse poorly into ocular tissue. The aim of our multicenter study was to assess whether eye involvement was more common in patients initially treated with echinocandins. We performed a post hoc analy...

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Published in:Diagnostic microbiology and infectious disease 2017-06, Vol.88 (2), p.141-144
Main Authors: Muñoz, P, Vena, A, Padilla, B, Valerio, M, Sanchez, M.I, Puig-Asensio, M, Fortún, J, Fernández-Ruiz, M, Merino, P, Losa, J.E, Loza, A, Rivas, R.A, Bouza, E
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
Candida endophthalmitis
Candidemia - drug therapy
Chorioretinitis - microbiology
Echinocandins
Echinocandins - therapeutic use
Endophthalmitis - microbiology
Eye Infections, Fungal - diagnosis
Eye Infections, Fungal - etiology
Eye Infections, Fungal - microbiology
Female
Humans
Infectious Disease
Initial antifungal therapy
Internal Medicine
Male
Middle Aged
Spain
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Summary:Abstract Candins are commonly used as initial therapy in patients with candidemia and are known to diffuse poorly into ocular tissue. The aim of our multicenter study was to assess whether eye involvement was more common in patients initially treated with echinocandins. We performed a post hoc analysis of a prospective, multicenter, population-based candidemic surveillance program implemented in Spain during 2010–2011 (CANDIPOP project). Eye involvement was detected in 13 of 168 patients with candidemia (7.7%) who underwent ophthalmoscopy. Two patients had endophthalmitis, while the remaining patients had chorioretinitis. The frequency of ocular candidiasis was similar in patients receiving initial therapy with candins (3/56; 5.4%) or with other regimens (10/112; 8.9%). At multivariate analysis, risk conditions for eye involvement were dialysis after candidemia (OR, 19.4; 95% CI, 1.7–218.4) and involvement of organs other than the eye (OR, 5.4; 95% CI, 1.1–25.7). In conclusion, eye involvement was not found to be more frequent in patients receiving initial therapy with echinocandins than in patients receiving other drugs.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2017.02.014