Zidovudine continuous infusion in an HIV-infected pregnant woman with a phobia of swallowing pills

The authors report the difficulties of preventing mother-to-child transmission in a pregnant HIV-infected woman with a phobia of swallowing pills. After multiple attempts and just as many failures, the authors ended up with cART consisting of small tablets of nevirapine, lamivudine and a continuous...

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Bibliographic Details
Published in:Antiviral therapy 2017-01, Vol.22 (8), p.727-729
Main Authors: van Luin, Matthijs, Ter Beest, Gerjanne, Wijnberger, Lia E, Swanink, Caroline Ma, Burger, David M, Gisolf, Jet H
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Female
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
Humans
Phobic Disorders - complications
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - virology
Treatment Outcome
Zidovudine - administration & dosage
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Summary:The authors report the difficulties of preventing mother-to-child transmission in a pregnant HIV-infected woman with a phobia of swallowing pills. After multiple attempts and just as many failures, the authors ended up with cART consisting of small tablets of nevirapine, lamivudine and a continuous intravenous infusion of zidovudine given via an elastomeric pump at home. This case demonstrates the difficulties that HIV physicians can encounter in pregnant women who have difficulties in swallowing tablets. In exceptional circumstances, continuous infusion of zidovudine may be an option, even in an outpatient setting.
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP3164