Long-term clinical outcomes and economic evaluation of the ketogenic diet versus care as usual in children and adolescents with intractable epilepsy

Highlights • The KD group resulted in more responders and showed greater improvement on seizure severity. • The KD did not lead to a worsening of side-effects other than gastro-intestinal problems (at 4 months follow-up only). • The costs of the total follow-up were higher in the KD group compared t...

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Bibliographic Details
Published in:Epilepsy research 2017-05, Vol.132, p.91-99
Main Authors: Wijnen, Ben F.M, de Kinderen, Reina J.A, Lambrechts, Danielle A.J.E, Postulart, Debby, Aldenkamp, Albert P, Majoie, Marian H.J.M, Evers, Silvia M.A.A
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Child
Child, Preschool
Children
Cost-Benefit Analysis
Diet, Ketogenic - methods
Drug Resistant Epilepsy - diet therapy
Drug Resistant Epilepsy - economics
Economic evaluations
Epilepsy
Female
Health Care Costs
Humans
Intractable epilepsy
Ketogenic diet
Male
Neurology
Quality of Life
Quality-Adjusted Life Years
Time
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Summary:Highlights • The KD group resulted in more responders and showed greater improvement on seizure severity. • The KD did not lead to a worsening of side-effects other than gastro-intestinal problems (at 4 months follow-up only). • The costs of the total follow-up were higher in the KD group compared to the control group. • As only a minimal difference was found between the KD and the CAU group regarding QALYs, inconclusive cost per QALY ratios resulted. • Compliance with the KD was shown to be difficult in some patients, resulting in a retention rate of 58% which is in line with previous literature.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2017.03.002