Effects of Cellular Electromechanical Coupling on Functional Heterogeneity in a One-Dimensional Tissue Model of the Myocardium

Abstract Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation pat...

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Bibliographic Details
Published in:Computers in biology and medicine 2017-05, Vol.84, p.147-155
Main Authors: Khokhlova, Anastasia, Balakina-Vikulova, Nathalie, Katsnelson, Leonid, Solovyova, Olga
Format: Article
Language:English
Subjects:
Action potential
Anatomy
Animal models
Animals
Aorta
Biomechanical Phenomena - physiology
Calcium
Calcium-binding protein
Cardiac arrhythmia
Cardiac heterogeneity
Cardiac mechanics
Cardiac muscle
Cardiomyocytes
Cell culture
Circuits
Computer applications
Deformation
Deformation effects
Depolarization
Dogs
Electromechanical coupling
Excitation-contraction coupling
Experimental data
Feedback
Guinea Pigs
Heart
Heart - physiology
Heart diseases
Heterogeneity
Homogeneity
Humans
Internal Medicine
Ion channels
Magnetic resonance imaging
Mechanical loading
Mechanical properties
Membrane currents
Membrane potential
Models, Cardiovascular
Muscle contraction
Myocardium
Myocardium - cytology
Myocytes, Cardiac - physiology
NMR
Nuclear magnetic resonance
One dimensional models
Other
Propagation
Pulmonary arteries
Regional development
Resonance
Strain
Velocity
Ventricle
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Summary:Abstract Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2017.03.021