Effects of Cellular Electromechanical Coupling on Functional Heterogeneity in a One-Dimensional Tissue Model of the Myocardium

Abstract Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation pat...

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Published in:Computers in biology and medicine 2017-05, Vol.84, p.147-155
Main Authors: Khokhlova, Anastasia, Balakina-Vikulova, Nathalie, Katsnelson, Leonid, Solovyova, Olga
Format: Article
Language:English
Subjects:
Action potential
Anatomy
Animal models
Animals
Aorta
Biomechanical Phenomena - physiology
Calcium
Calcium-binding protein
Cardiac arrhythmia
Cardiac heterogeneity
Cardiac mechanics
Cardiac muscle
Cardiomyocytes
Cell culture
Circuits
Computer applications
Deformation
Deformation effects
Depolarization
Dogs
Electromechanical coupling
Excitation-contraction coupling
Experimental data
Feedback
Guinea Pigs
Heart
Heart - physiology
Heart diseases
Heterogeneity
Homogeneity
Humans
Internal Medicine
Ion channels
Magnetic resonance imaging
Mechanical loading
Mechanical properties
Membrane currents
Membrane potential
Models, Cardiovascular
Muscle contraction
Myocardium
Myocardium - cytology
Myocytes, Cardiac - physiology
NMR
Nuclear magnetic resonance
One dimensional models
Other
Propagation
Pulmonary arteries
Regional development
Resonance
Strain
Velocity
Ventricle
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cited_by cdi_FETCH-LOGICAL-c494t-738819c99755b3a847860f740f125046d7dc30beecd6e0ad6343ac89d9b4404f3
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container_issue
container_start_page 147
container_title Computers in biology and medicine
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creator Khokhlova, Anastasia
Balakina-Vikulova, Nathalie
Katsnelson, Leonid
Solovyova, Olga
description Abstract Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.
doi_str_mv 10.1016/j.compbiomed.2017.03.021
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The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2017.03.021</identifier><identifier>PMID: 28364644</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Action potential ; Anatomy ; Animal models ; Animals ; Aorta ; Biomechanical Phenomena - physiology ; Calcium ; Calcium-binding protein ; Cardiac arrhythmia ; Cardiac heterogeneity ; Cardiac mechanics ; Cardiac muscle ; Cardiomyocytes ; Cell culture ; Circuits ; Computer applications ; Deformation ; Deformation effects ; Depolarization ; Dogs ; Electromechanical coupling ; Excitation-contraction coupling ; Experimental data ; Feedback ; Guinea Pigs ; Heart ; Heart - physiology ; Heart diseases ; Heterogeneity ; Homogeneity ; Humans ; Internal Medicine ; Ion channels ; Magnetic resonance imaging ; Mechanical loading ; Mechanical properties ; Membrane currents ; Membrane potential ; Models, Cardiovascular ; Muscle contraction ; Myocardium ; Myocardium - cytology ; Myocytes, Cardiac - physiology ; NMR ; Nuclear magnetic resonance ; One dimensional models ; Other ; Propagation ; Pulmonary arteries ; Regional development ; Resonance ; Strain ; Velocity ; Ventricle</subject><ispartof>Computers in biology and medicine, 2017-05, Vol.84, p.147-155</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. 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ispartof Computers in biology and medicine, 2017-05, Vol.84, p.147-155
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1879-0534
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source ScienceDirect Freedom Collection 2022-2024
subjects Action potential
Anatomy
Animal models
Animals
Aorta
Biomechanical Phenomena - physiology
Calcium
Calcium-binding protein
Cardiac arrhythmia
Cardiac heterogeneity
Cardiac mechanics
Cardiac muscle
Cardiomyocytes
Cell culture
Circuits
Computer applications
Deformation
Deformation effects
Depolarization
Dogs
Electromechanical coupling
Excitation-contraction coupling
Experimental data
Feedback
Guinea Pigs
Heart
Heart - physiology
Heart diseases
Heterogeneity
Homogeneity
Humans
Internal Medicine
Ion channels
Magnetic resonance imaging
Mechanical loading
Mechanical properties
Membrane currents
Membrane potential
Models, Cardiovascular
Muscle contraction
Myocardium
Myocardium - cytology
Myocytes, Cardiac - physiology
NMR
Nuclear magnetic resonance
One dimensional models
Other
Propagation
Pulmonary arteries
Regional development
Resonance
Strain
Velocity
Ventricle
title Effects of Cellular Electromechanical Coupling on Functional Heterogeneity in a One-Dimensional Tissue Model of the Myocardium
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