Synthesis of New Substituted 5-amino-8H-phthalazino[1,2-b]quinazolin-8-one Derivatives

A series of novel substituted 5-amino-8H-phthalazino[1,2-b]quinazolin-8-one derivatives synthesised by condensation of different amines with 5-chloro-8H-phthalazino[1,2-b]quinazolin-8-one, which was prepared from methyl 2-aminobenzoate by condensation with hydrazine hydrate and then cyclisation with...

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Bibliographic Details
Published in:Journal of chemical research 2017-01, Vol.41 (1), p.18-20
Main Authors: Liu, Ju, Hao, Xue-Chen, Chen, Ye, Ding, Shi, Liu, Hong-Sheng, Wang, Dan
Format: Article
Language:English
Subjects:
Condensation
Derivatives
Filtration
Hydrates
Hydrazines
Phthalic anhydride
Refluxing
Synthesis
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Summary:A series of novel substituted 5-amino-8H-phthalazino[1,2-b]quinazolin-8-one derivatives synthesised by condensation of different amines with 5-chloro-8H-phthalazino[1,2-b]quinazolin-8-one, which was prepared from methyl 2-aminobenzoate by condensation with hydrazine hydrate and then cyclisation with a phthalic anhydride in N,N-dimethylacetamide at refluxing condition. The intermediate and target compounds were obtained in good yields and were easily purified by filtration or recrystallisation.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751917X14815427219167