Fighting the enemy within

The dynamic microbiota that populate all human body surfaces affect health and disease in complex and often subtle ways. At the same time, human gastrointestinal and respiratory tract microbiota are the reservoirs for most of the human pathogens that cause invasive bacterial infections. Antibiotic r...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2017-02, Vol.355 (6326), p.689-690
Main Authors: Tacconelli, Evelina, Autenrieth, Ingo B., Peschel, Andreas
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Bacteria
Bacteria - drug effects
Bacteria - pathogenicity
Bacterial infections
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Bacterial Infections - prevention & control
Bacterial Load - drug effects
Community-Acquired Infections - drug therapy
Community-Acquired Infections - prevention & control
Disinfectants - pharmacology
Drug Design
Drug Resistance, Bacterial
Dynamics
Gastrointestinal tract
Health
Health risks
Human body
Humans
Infections
Microbiota - drug effects
Microorganisms
Pathogens
PERSPECTIVES
R&D
Research & development
Research and development
Reservoirs
Respiratory tract
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Summary:The dynamic microbiota that populate all human body surfaces affect health and disease in complex and often subtle ways. At the same time, human gastrointestinal and respiratory tract microbiota are the reservoirs for most of the human pathogens that cause invasive bacterial infections. Antibiotic resistance in such pathogens has dramatically increased in recent years, resulting in infections that are much more difficult to treat (1, 2). To counter this rise, research and development efforts must target not only new broad-spectrum antibiotics, but also decolonization agents that disrupt the major endogenous reservoirs of antibiotic-resistant bacterial pathogens (ARBPs) and reduce the risk of infections that do not respond to treatment.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aam6372