Mild Cu(OAc)2.H2O-catalyzed synthesis of multi-substituted 1,2,4-triazoles from amidines with nitriles via a N-N/C-N coupling

A simple and efficient Cu(OAc)2.H2O-catalyzed aerobic oxidation of amidines with nitriles for the synthesis of multi-substituted 1,2,4-triazoles has been achieved. The procedure constructs multi-substituted 1,2,4-triazoles and has the advantages of operational simplicity, broad substrate scope, and...

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Published in:RSC advances 2015-09, Vol.5 (96), p.78422-78426
Main Authors: Wang, Fei, You, Qing, Wu, Chaoting, Min, Dewen, Shi, Tianchao, Kong, Yuting, Zhang, Wu
Format: Article
Language:English
Subjects:
Bonding
Cascades
Coupling
Nitriles
Oxidation
Reagents
Substrates
Synthesis
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container_issue 96
container_start_page 78422
container_title RSC advances
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creator Wang, Fei
You, Qing
Wu, Chaoting
Min, Dewen
Shi, Tianchao
Kong, Yuting
Zhang, Wu
description A simple and efficient Cu(OAc)2.H2O-catalyzed aerobic oxidation of amidines with nitriles for the synthesis of multi-substituted 1,2,4-triazoles has been achieved. The procedure constructs multi-substituted 1,2,4-triazoles and has the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents. A possible mechanism has been proposed via the cascade N-H functionalization and N-N/C-N bond formation.
doi_str_mv 10.1039/c5ra15919a
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subjects Bonding
Cascades
Coupling
Nitriles
Oxidation
Reagents
Substrates
Synthesis
title Mild Cu(OAc)2.H2O-catalyzed synthesis of multi-substituted 1,2,4-triazoles from amidines with nitriles via a N-N/C-N coupling
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