A Pd( ii )-catalyzed C–H activation approach to densely functionalized N-heteroaromatics related to neocryptolepine and their evaluation as potential inducers of apoptosis

11-Carboxymethyl substituted 6 H -indolo[2,3- b ]quinolines, which are potential inducers of apoptosis, were obtained by one-pot Pd( ii )-catalyzed intramolecular oxidative C3–H alkenylation of the indole ring of ( E )-alkyl-3-(2-(1 H -indol-2-ylamino)phenyl)acrylate derivatives followed by desulfon...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (56), p.44722-44727
Main Authors: Sunke, Rajnikanth, Kumar, Vimal, Ashfaq, Mohd Ashraf, Yellanki, Swapna, Medisetti, Raghavender, Kulkarni, Pushkar, Shivaji Ramarao, E. V. Venkat, Ehtesham, Nasreen Z., Pal, Manojit
Format: Article
Language:English
Subjects:
Activation
Activation analysis
Apoptosis
Derivatives
Indoles
Inducers
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Summary:11-Carboxymethyl substituted 6 H -indolo[2,3- b ]quinolines, which are potential inducers of apoptosis, were obtained by one-pot Pd( ii )-catalyzed intramolecular oxidative C3–H alkenylation of the indole ring of ( E )-alkyl-3-(2-(1 H -indol-2-ylamino)phenyl)acrylate derivatives followed by desulfonylation.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA06764B